Chalcomoracin Prevents Vitreous-Induced Activation of AKT and Migration of Retinal Pigment Epithelial Cells

Haote Han; Yanhui Yang; Bing Liu; Jingkui Tian; Wei Zhu; Jiantao Wang; Hetian Lei

doi:10.20944/preprints202004.0312.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 18 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (02:18:01 CEST)

Retinal pigment epithelial (RPE) cells are the major cell type in the epi- or sub-retinal membranes in the pathogenesis of proliferative vitreoretinopathy (PVR), which is a blinding fibrotic eye disease and still short of effective medicine. The purpose of this study is to demonstrate if Chalocomoracin (CMR), a novel purified compound from fungus-infected mulberry leaves, is able to inhibit vitreous-induced signaling events and cellular responses intrinsic to PVR. Our studies have revealed that the CMR IC50 for ARPE-19 cells is 35.5 μM at 72 hours, and that 5 μM CMR inhibits vitreous-induced Akt activation and p53 suppression; in addition we have discovered that this chemical effectively blocks vitreous-stimulated proliferation, migration and contraction of ARPE-19 cells, suggesting that CMR is a promising PVR prophylactic.

chalocomoracin; proliferative vitreoretinopathy; vitreous; Akt; p53; migration; proliferation; contraction

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Chalcomoracin Prevents Vitreous-Induced Activation of AKT and Migration of Retinal Pigment Epithelial Cells

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