Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

Mass Intake of Hydroxychloroquine or Chloroquine in the Present Context of the COVID-19 Outbreak: Possible Consequences in Endemic Malaria Settings

Version 1 : Received: 12 April 2020 / Approved: 13 April 2020 / Online: 13 April 2020 (07:47:36 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Medical Hypotheses 2020, 143
DOI: 10.1016/j.mehy.2020.109912

Abstract

World is currently experiencing a new pandemic for which no curative treatment is available. At this time, coronavirus disease 2019 (Covid-19) has reached 183 countries and has caused several deaths. Many reports presented chloroquine (CQ) and hydrochloroquine (HCQ), former drugs used against malaria, as the best current choice to fight this terrible disease. As these molecules had been withdrawn in malaria treatment policy due to chemoresistance, their reintroduction could have some consequences. Though local malaria prevalence could decrease for a while, molecular changes are likely to happen on some plasmodium falciparum genes involved in conferring drug resistance. This could threaten efforts in malaria control, if these molecules are widely administered.

Subject Areas

malaria; COVID-19; SARS-COV-2; chloroquine; hydroxychloroquine

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