Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight-Loss Programme - A Double Blind Randomized Placebo-Controlled Trial

Michał Brzeziński
* ORCID logo ,
Agnieszka Jankowska
,
Magdalena Słomińska-Frączek
,
Paulina Metelska
ORCID logo ,
Piotr Wiśniewski
,
Piotr Socha
,
Agnieszka Szlagatys-Sidorkiewicz
Version 1 : Received: 10 April 2020 / Approved: 12 April 2020 / Online: 12 April 2020 (16:44:13 CEST)

A peer-reviewed article of this Preprint also exists.

Brzeziński, M.; Jankowska, A.; Słomińska-Frączek, M.; Metelska, P.; Wiśniewski, P.; Socha, P.; Szlagatys-Sidorkiewicz, A. Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight–Loss Programme—A Double Blind Randomized Placebo–Controlled Trial. Nutrients 2020, 12, 1093. Brzeziński, M.; Jankowska, A.; Słomińska-Frączek, M.; Metelska, P.; Wiśniewski, P.; Socha, P.; Szlagatys-Sidorkiewicz, A. Long-Term Effects of Vitamin D Supplementation in Obese Children During Integrated Weight–Loss Programme—A Double Blind Randomized Placebo–Controlled Trial. Nutrients 2020, 12, 1093.

Abstract

Background: Vitamin D was studied in regards to its possible impact on body mass reduction and metabolic changes in adults and children with obesity yet there were no studies assessing the impact of vitamin D supplementation during a weight management programme in children and adolescence. The aim of our study was to assess the influence of 26 weeks of vitamin D supplementation in overweight and obese children undergoing an integrated 12-months’ long weight loss programme on body mass reduction, body composition and bone mineral density. Methods: A double-blind randomized placebo-controlled trial. Vitamin D deficient patients ( <30 ng/ml level of vitamin D) aged 6-14, participating in multidisciplinary weight management programme were randomly allocated to receiving vitamin D (1200 IU) or placebo for the first 26 weeks of the intervention. Results: Out of the 152 qualified patients, 109 (72%) completed a full cycle of four visits scheduled in the programme. There were no difference in the level of BMI change. Although the reduction was greater in the vitamin D vs. placebo group (-4.28 ± 8.43 vs. -2.53 ±6.10) the difference was not statistically significant (p=0.319). Similarly the reduction in fat mass – assessed both using bioimpedance and DEXa was achieved, yet the differences between the groups were not statistically significant. Conclusions: Our study ads substantial results to support the thesis on no effect of vitamin D supplementation on body weight reduction in children and adolescents with vitamin D insufficiency undergoing a weight management programme. Trial registration no: NCT 02828228; trial registration date: 8 June 2016 registered in: ClinicalTrials.gov.

Keywords

vitamin D; obesity; weight-loss; body composition

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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