Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective

Version 1 : Received: 8 April 2020 / Approved: 10 April 2020 / Online: 10 April 2020 (02:34:36 CEST)
Version 2 : Received: 16 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (06:51:53 CEST)

How to cite: Brogna, C. The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints 2020, 2020040165. Brogna, C. The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints 2020, 2020040165.


Acetylcholine (ACh) is the best one characterized neurotransmitter. Its central roles in the cholinergic areas and central nervous system (CNS) and peripheral (PNS) synapses are well known. It was the first molecule identified as a neurotransmitter and appears to be phylogenetically the oldest one signaling molecules. ACh was detected in bacteria, protozoa, fungi, algae and primitive plants, indicating that the cholinergic system was widely distributed in living organisms before its appearance in the nervous system. The autonomous nervous system (ANS) is an integral part animal kingdom history. It determines fight-escape reactions as well as outlining the vital and cognitive functions bio-organization rhythms. The virus (Covid-19) extraneous effects acting on it could help to better understand its functions. The Blast results show some factors like protein that can be implicated such as bungaro-toxins, phospholipase A2 and the similar prothrombin activator protein. A positive correlation with different toxins is obtained and the Covid-19 double pathogenic mechanism theory is proposed. The process allows us to outline the possibility about toxic-like factors presence.


Covid-19; Blastn; toxins protein; ACh; aChE; BuChE; CBP; Zero Point; bungaro-toxins, phospholipase A2; similar prothrombin activator protein


Medicine and Pharmacology, Pharmacology and Toxicology

Comments (2)

Comment 1
Received: 19 April 2020
Commenter: Carlo Brogna
Commenter's Conflict of Interests: Author
Comment: The title is changed in “The Covid-19 virus double pathogenic mechanism. A new perspective”.
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Comment 2
Received: 22 May 2020
The commenter has declared there is no conflict of interests.
Comment: The aCh receptor are colinergic receptor. They are divided into 2 type: nicotinic and muscarin.
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