The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective

Carlo Brogna

doi:10.20944/preprints202004.0165.v2

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preprints.org > medicine and pharmacology > pharmacology and toxicology > doi: 10.20944/preprints202004.0165.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective

Carlo Brogna

Version 1 : Received: 8 April 2020 / Approved: 10 April 2020 / Online: 10 April 2020 (02:34:36 CEST)
Version 2 : Received: 16 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (06:51:53 CEST)

How to cite: Brogna, C. The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints 2020, 2020040165. https://doi.org/10.20944/preprints202004.0165.v2 Brogna, C. The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints 2020, 2020040165. https://doi.org/10.20944/preprints202004.0165.v2

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MDPI and ACS Style

Brogna, C. The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints 2020, 2020040165. https://doi.org/10.20944/preprints202004.0165.v2

APA Style

Brogna, C. (2020). The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective. Preprints. https://doi.org/10.20944/preprints202004.0165.v2

Chicago/Turabian Style

Brogna, C. 2020 "The Covid-19 Virus Double Pathogenic Mechanism. A New Perspective" Preprints. https://doi.org/10.20944/preprints202004.0165.v2

Abstract

Acetylcholine (ACh) is the best one characterized neurotransmitter. Its central roles in the cholinergic areas and central nervous system (CNS) and peripheral (PNS) synapses are well known. It was the first molecule identified as a neurotransmitter and appears to be phylogenetically the oldest one signaling molecules. ACh was detected in bacteria, protozoa, fungi, algae and primitive plants, indicating that the cholinergic system was widely distributed in living organisms before its appearance in the nervous system. The autonomous nervous system (ANS) is an integral part animal kingdom history. It determines fight-escape reactions as well as outlining the vital and cognitive functions bio-organization rhythms. The virus (Covid-19) extraneous effects acting on it could help to better understand its functions. The Blast results show some factors like protein that can be implicated such as bungaro-toxins, phospholipase A2 and the similar prothrombin activator protein. A positive correlation with different toxins is obtained and the Covid-19 double pathogenic mechanism theory is proposed. The process allows us to outline the possibility about toxic-like factors presence.

Keywords

Covid-19; Blastn; toxins protein; ACh; aChE; BuChE; CBP; Zero Point; bungaro-toxins, phospholipase A2; similar prothrombin activator protein

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (2)

Comment 1

Received: 19 April 2020
Commenter: Carlo Brogna
Commenter's Conflict of Interests: Author

Comment: The title is changed in “The Covid-19 virus double pathogenic mechanism. A new perspective”.

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Comment 2

Received: 22 May 2020
Commenter:

Carlo Brogna

The commenter has declared there is no conflict of interests.

Comment: The aCh receptor are colinergic receptor. They are divided into 2 type: nicotinic and muscarin.

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