Working Paper Article Version 1 This version is not peer-reviewed

SARS-CoV-2 Infection of Cats and Dogs?

Version 1 : Received: 7 April 2020 / Approved: 8 April 2020 / Online: 8 April 2020 (04:43:14 CEST)

How to cite: Shen, M.; Liu, C.; Xu, R.; Ruan, Z.; Zhao, S.; Zhang, H.; Wang, W.; Huang, X.; Yang, L.; Tang, Y.; Yang, T.; Jia, X. SARS-CoV-2 Infection of Cats and Dogs?. Preprints 2020, 2020040116 Shen, M.; Liu, C.; Xu, R.; Ruan, Z.; Zhao, S.; Zhang, H.; Wang, W.; Huang, X.; Yang, L.; Tang, Y.; Yang, T.; Jia, X. SARS-CoV-2 Infection of Cats and Dogs?. Preprints 2020, 2020040116

Abstract

SARS-CoV-2 causes severe pneumonia epidemics and probably originated in horseshoe bats, but the intermediate host is unknown. The interaction of SARS-CoV-2 spike protein and its acceptor protein ACE2 is an important issue in determining viral host range and cross-species infection, while the binding capacity of Spike protein to ACE2 of different species is unknown. Here, we used the atomic structure model of SARS-CoV-2 and human ACE2 to assess the receptor utilization capacity of ACE2s from different species including cats, chimpanzees, dogs, cattles. Our results show, domestic cats (Felis catusc) and dogs (Canis lupus familiaris) are more susceptible to infection by SARS-CoV-2 and that they can efficiently transmit the virus to previously uninfected animals that are housed with them. Especially, cats could be a choice of animal model for screening antiviral drugs or vaccine candidates against SARS-CoV-2.

Subject Areas

SARS-CoV-2; angiotensin-converting enzyme 2 (ACE2); animal reservoir; cross-species transmission; cats

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