Version 1
: Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (15:12:34 CET)
Version 2
: Received: 29 March 2020 / Approved: 30 March 2020 / Online: 30 March 2020 (08:25:51 CEST)
How to cite:
Singh, B. Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints2020, 2020030394. https://doi.org/10.20944/preprints202003.0394.v1
Singh, B. Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints 2020, 2020030394. https://doi.org/10.20944/preprints202003.0394.v1
Singh, B. Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints2020, 2020030394. https://doi.org/10.20944/preprints202003.0394.v1
APA Style
Singh, B. (2020). Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints. https://doi.org/10.20944/preprints202003.0394.v1
Chicago/Turabian Style
Singh, B. 2020 "Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein" Preprints. https://doi.org/10.20944/preprints202003.0394.v1
Abstract
The recent outbreak of novel coronavirus (2019-nCoV or SARS-CoV-2) and its spread to the whole world is currently posing one of the major threat to human health and the world economy. It has been suggested that 2019-nCoV is similar to SARS-CoV based on the genome sequence comparison. Despite the genomic similarity between SARS-CoV and SARS-CoV-2, the spike glycoprotein and receptor binding domain in SARS-CoV-2 shows considerable difference compared to SARS-CoV, due to the presence of several point mutations. We analyzed the receptor binding domain (RBD) from recently published 3D structure of spike glycoprotein of SARS-CoV-2 and compared with RBD of SARS-CoV. The observations highlight few important features of RBD in the light of the recently published findings from the 3D structures of spike glycoprotein and its complex with human angiotensin-converting enzyme 2 (ACE2) (Yan, R., et al. (2020); Wrapp, D., et al. (2020); Walls, A. C., et al. (2020)).
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
