Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein

Version 1 : Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (15:12:34 CET)
Version 2 : Received: 29 March 2020 / Approved: 30 March 2020 / Online: 30 March 2020 (08:25:51 CEST)

How to cite: Singh, B. Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints 2020, 2020030394 (doi: 10.20944/preprints202003.0394.v1). Singh, B. Understanding the Role of Key Point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. Preprints 2020, 2020030394 (doi: 10.20944/preprints202003.0394.v1).

Abstract

The recent outbreak of novel coronavirus (2019-nCoV or SARS-CoV-2) and its spread to the whole world is currently posing one of the major threat to human health and the world economy. It has been suggested that 2019-nCoV is similar to SARS-CoV based on the genome sequence comparison. Despite the genomic similarity between SARS-CoV and SARS-CoV-2, the spike glycoprotein and receptor binding domain in SARS-CoV-2 shows considerable difference compared to SARS-CoV, due to the presence of several point mutations. We analyzed the receptor binding domain (RBD) from recently published 3D structure of spike glycoprotein of SARS-CoV-2 and compared with RBD of SARS-CoV. The observations highlight few important features of RBD in the light of the recently published findings from the 3D structures of spike glycoprotein and its complex with human angiotensin-converting enzyme 2 (ACE2) (Yan, R., et al. (2020); Wrapp, D., et al. (2020); Walls, A. C., et al. (2020)).

Subject Areas

Covid-19; SARS-CoV-2; ACE2; Coronavirus; 2019-nCoV

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