Preprint Hypothesis Version 1 This version is not peer-reviewed

Ab Initio Modelling the Structure of Proton-Sensing G-Protein Coupled Receptor GPR151

Wei Li * ORCID logo
Version 1 : Received: 18 March 2020 / Approved: 20 March 2020 / Online: 20 March 2020 (04:25:00 CET)

How to cite: Li, W. Ab Initio Modelling the Structure of Proton-Sensing G-Protein Coupled Receptor GPR151. Preprints 2020, 2020030304 (doi: 10.20944/preprints202003.0304.v1). Li, W. Ab Initio Modelling the Structure of Proton-Sensing G-Protein Coupled Receptor GPR151. Preprints 2020, 2020030304 (doi: 10.20944/preprints202003.0304.v1).

Abstract

Protein is the proteios building block of life. Evolutionarily, its sequence is not as conserved as its structure, making it more reasonable for protein structure, instead of protein sequence, to be the descriptor of protein function. Yet, in the National Center for Biotechnology Information (NCBI) database, the number of experimentally identified protein sequences is in great excess of that of experimentally determined protein structures inside the almost-half-a-century old Protein Data Bank (PDB). For instance, GPR151 is an proton-sensing G-protein coupled receptor (GPCR) originally identified as homologous to galanin receptors. As of March 19, 2020, GPR151’s structure has not been experimentally determined and deposited in PDB yet. Thus, an ab initio modelling approach was employed here to build a three-dimensional structure of GPR151. Overall, the ab initio GPR151 model presented herein constitutes the first structural hypothesis of GPR151 to be experimentally tested in future with previously published, currently ongoing and future GPR151 studies.

Subject Areas

Ab Initio modelling; three-dimensional structure; proton-sensing G-protein coupled receptor (GPCR); GPR151

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