Preserved in Portico This version is not peer-reviewed
First Case of COVID-19 Infection with Fulminant Myocarditis Complication: Case Report and Insights
: Received: 10 March 2020 / Approved: 11 March 2020 / Online: 11 March 2020 (04:57:10 CET)
: Received: 3 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (01:03:22 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Infection 2020
Background: The Coronavirus Disease 2019 (COVID-19) has been demonstrated as the cause of pneumonia. Nevertheless, it has not been reported as the cause of acute myocarditis or fulminant myocarditis. Case Presentation: A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as COVID-19 by testing sputum on the first day of admission. He also had an elevated troponin-I (Trop I) level and diffuse myocardial dyskinesia along with decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of Interleukin 6 was 272.40pg/ml. Bedside chest radiograph had typical ground-glass changes of viral pneumonia. The laboratory test results of virus that can cause myocarditis are all negative. The patient conformed to the diagnostic criteria of Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, the Trop I reduced to 0.10 g/L, and Interleukin 6 was 7.63 pg/ml. Meanwhile the LVEF of the patient gradually recovered to 68%. Conclusion: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure, and this is the first case of COVID-19 infection complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study.
COVID-19; coronavirus; fulminant myocarditis; infection; echocardiography
LIFE SCIENCES, Virology
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