Working Paper Article Version 1 This version is not peer-reviewed

Lung Adenocarcinoma Patients Own Higher Risk of SARS-CoV-2 Infection

Version 1 : Received: 25 February 2020 / Approved: 26 February 2020 / Online: 26 February 2020 (02:50:17 CET)

How to cite: Chen, L.; Zhong, L. Lung Adenocarcinoma Patients Own Higher Risk of SARS-CoV-2 Infection. Preprints 2020, 2020020386 Chen, L.; Zhong, L. Lung Adenocarcinoma Patients Own Higher Risk of SARS-CoV-2 Infection. Preprints 2020, 2020020386

Abstract

Both lung adenocarcinoma and SARS-CoV-2 infection could cause pulmonary inflammation. Angiotensin-converting enzyme 2, not only as the functional receptor of SARS-CoV-2 but also play key role in lung adenocarcinoma. To study the risk of SARS-CoV-2 infection in lung adenocarcinoma patients, mRNA and miRNA profiles were obtained from TCGA and GEO databases followed by bioinformatics analysis. A regulatory network which regards angiotensin-converting enzyme 2 as the center would be structured. In addition, via immunological analysis about key factors in lung adenocarcinoma patients, to explore the essential reasons for the susceptibility of SARS-CoV-2. Compared with normal tissue, angiotensin-converting enzyme 2 was increased in lung adenocarcinoma patients. Furthermore, a total of 7 differently expressed correlated mRNAs (ACE2, CXCL9, MMP12, IL6, AZU1, FCN3, HYAL1 and IRAK3) and 5 differently expressed correlated miRNAs (miR-125b-5p, miR-9-5p, miR-130b-5p, miR-381-3p and miR-421) were screened followed by enrichment analysis. Interestingly, toll-like receptor signaling pathway with the most frequent occurrence was enriched by mRNA (IL6) and miRNA (miR-125b-5p) sets simultaneously. Finally through comprehensive analysis, it was assumed that miR-125b-5p-ACE2-IL6 axis in the structured regulatory network could alter risk of SARS-CoV-2 infection in lung adenocarcinoma patients.

Subject Areas

lung adenocarcinoma; SARS-CoV-2; ACE2; miR-125b-5p; IL6

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