Working Paper Article Version 1 This version is not peer-reviewed

High-Sensitivity Detection of IgG Operating Near the Dispersion Turning Point in Tapered Two-Mode Fibers

Version 1 : Received: 19 February 2020 / Approved: 20 February 2020 / Online: 20 February 2020 (05:33:03 CET)

A peer-reviewed article of this Preprint also exists.

Sun, B.; Wang, Y. High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers. Micromachines 2020, 11, 270. Sun, B.; Wang, Y. High-Sensitivity Detection of IgG Operating near the Dispersion Turning Point in Tapered Two-Mode Fibers. Micromachines 2020, 11, 270.

Journal reference: Micromachines 2020, 11, 270
DOI: 10.3390/mi11030270

Abstract

Conventional method for monitoring the IgG levels suffered from some apparent problems such as long assay time, multistep processing, and high overall cost. An effective and suitable optical platform for label-free biosensing has been investigated by the implementation of antibody/antigen immunoassays. Thus, the ultrasensitive detection of IgG levels can be achieved by exploiting the dispersion turning point (DTP) existed in the tapered two-mode fibers (TTMFs) due to the sensitivity will reach ±∞ on either side of the DTP. Tracking the resonant wavelength shift it was found that the fabricated TTMF device exhibited limits of detection (LOD) down up to concentrations of 10 fg/mL of IgG in PBS solution. Such immunosensors based on the DTP have great significance on trace detection of IgG due to simple detection scheme, quick response time, and miniaturation.

Subject Areas

biosensor; optical fiber sensor; two-mode fiber; sensitivity

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