Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Asians and Other Races Express Similar Levels of and Share the Same Genetic Polymorphisms of the SARS-CoV-2 Cell-Entry Receptor

Version 1 : Received: 17 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (06:40:01 CET)
Version 2 : Received: 24 February 2020 / Approved: 25 February 2020 / Online: 25 February 2020 (06:30:17 CET)

How to cite: Chen, Y.; Shan, K.; Qian, W. Asians and Other Races Express Similar Levels of and Share the Same Genetic Polymorphisms of the SARS-CoV-2 Cell-Entry Receptor. Preprints 2020, 2020020258 (doi: 10.20944/preprints202002.0258.v1). Chen, Y.; Shan, K.; Qian, W. Asians and Other Races Express Similar Levels of and Share the Same Genetic Polymorphisms of the SARS-CoV-2 Cell-Entry Receptor. Preprints 2020, 2020020258 (doi: 10.20944/preprints202002.0258.v1).

Abstract

The recurrent coronavirus outbreaks in China (SARS-CoV and its relative, SARS-CoV-2) raise the possibility that Asians are more susceptible to coronavirus. Here, we test this possibility with the lung expression of ACE2, which encodes the cell-entry receptor of both SARS-CoV and SARS-CoV-2. We show that ACE2 expression is not affected during tumorigenesis, suggesting that the transcriptome data from the more than 1000 lung cancer samples in The Cancer Genome Atlas (TCGA) can be used to study ACE2 expression among people without cancer. The expression of ACE2 increases with age, but is not associated with sex. Asians show a similar ACE2 expression to other races. Furthermore, the frequencies of ACE2 alleles in Asians are not significantly deviated from those in other races. These observations indicate that individuals of all races need the same level of personal protection against SARS-CoV-2.

Subject Areas

SARS-CoV-2; cell-entry receptor; ACE2 expression; The Cancer Genome Atlas; susceptibility; demographic factors; race

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