Working Paper Article Version 1 This version is not peer-reviewed

Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice

Version 1 : Received: 16 February 2020 / Approved: 17 February 2020 / Online: 17 February 2020 (01:00:26 CET)

How to cite: Zhou, H.; Wang, G.; Luo, L.; Ding, W.; Xu, J.; Qin, L.; Wan, Z. Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints 2020, 2020020228 Zhou, H.; Wang, G.; Luo, L.; Ding, W.; Xu, J.; Qin, L.; Wan, Z. Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints 2020, 2020020228

Abstract

Existing evidence suggest that lactoferrin might be beneficial for Alzheimer’s disease. We aimed to determine the effects of lactoferrin intervention on cognitive function from APP/PS1 mice, and possible mechanisms involved in. Both young and middle-aged male APP/PS1 mice were divided into control and lactoferrin group with 16 weeks’ intervention. Lactoferrin intervention had no effects on cognitive function from both young and middle-aged mice, and no key markers involved in Aβ, tau pathology, neuro-inflammation and synaptic plasticity were altered post lactoferrin intervention. In regards to gut microbiota profiles, in the young mice, lactoferrin elevated α diversity index including ACE and Chao 1, and reduced the relative abundance of the genera Bacteroides and Alistipes and elevated Oscillibacter, in addition, Oscillibacter, Anaerotruncus, EF096579_g, EU454405_g, Mollicutes_RF39, EU474361_g, EU774448_g, and EF096976_g were specifically abundant post Lf intervention via LEfSe analysis. In the middle-aged mice, the relative abundance of the phylum Proteobacteria, as well as the genera Oscillospira, Coprococcus and Ruminococcus was significantly reduced post Lf intervention, additionally, S24_7, Bacteroidia, Bacteroidetes and Methylobacterium were specific via LEfSe analysis post lactoferrin intervention. In conclusion, dietary lactoferrin might be beneficial for gut microbiota homeostasis although might have no effects on cognition.

Subject Areas

Alzheimer’s disease; lactoferrin; cognitive function; gut microbiota; amyloid β

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.