Version 1
: Received: 16 February 2020 / Approved: 17 February 2020 / Online: 17 February 2020 (01:00:26 CET)
How to cite:
Zhou, H.; Wang, G.; Luo, L.; Ding, W.; Xu, J.; Qin, L.; Wan, Z. Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints2020, 2020020228
Zhou, H.; Wang, G.; Luo, L.; Ding, W.; Xu, J.; Qin, L.; Wan, Z. Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints 2020, 2020020228
Zhou, H.; Wang, G.; Luo, L.; Ding, W.; Xu, J.; Qin, L.; Wan, Z. Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints2020, 2020020228
APA Style
Zhou, H., Wang, G., Luo, L., Ding, W., Xu, J., Qin, L., & Wan, Z. (2020). Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice. Preprints. https://doi.org/
Chicago/Turabian Style
Zhou, H., Li-Qiang Qin and Zhongxiao Wan. 2020 "Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice" Preprints. https://doi.org/
Abstract
Existing evidence suggest that lactoferrin might be beneficial for Alzheimer’s disease. We aimed to determine the effects of lactoferrin intervention on cognitive function from APP/PS1 mice, and possible mechanisms involved in. Both young and middle-aged male APP/PS1 mice were divided into control and lactoferrin group with 16 weeks’ intervention. Lactoferrin intervention had no effects on cognitive function from both young and middle-aged mice, and no key markers involved in Aβ, tau pathology, neuro-inflammation and synaptic plasticity were altered post lactoferrin intervention. In regards to gut microbiota profiles, in the young mice, lactoferrin elevated α diversity index including ACE and Chao 1, and reduced the relative abundance of the genera Bacteroides and Alistipes and elevated Oscillibacter, in addition, Oscillibacter, Anaerotruncus, EF096579_g, EU454405_g, Mollicutes_RF39, EU474361_g, EU774448_g, and EF096976_g were specifically abundant post Lf intervention via LEfSe analysis. In the middle-aged mice, the relative abundance of the phylum Proteobacteria, as well as the genera Oscillospira, Coprococcus and Ruminococcus was significantly reduced post Lf intervention, additionally, S24_7, Bacteroidia, Bacteroidetes and Methylobacterium were specific via LEfSe analysis post lactoferrin intervention. In conclusion, dietary lactoferrin might be beneficial for gut microbiota homeostasis although might have no effects on cognition.
Keywords
Alzheimer’s disease; lactoferrin; cognitive function; gut microbiota; amyloid β
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
