Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV

Yanyan Zhu; Miaomiao Jiang; Liang Gao; Xiaoyun Huang

doi:10.20944/preprints202002.0221.v1

Preprint Article Version 1 This version is not peer-reviewed

Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV

Yanyan Zhu ,

Miaomiao Jiang ,

Liang Gao ,

Xiaoyun Huang ^*

Version 1 : Received: 15 February 2020 / Approved: 16 February 2020 / Online: 16 February 2020 (14:56:57 CET)

How to cite: Zhu, Y.; Jiang, M.; Gao, L.; Huang, X. Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints 2020, 2020020221 (doi: 10.20944/preprints202002.0221.v1). Zhu, Y.; Jiang, M.; Gao, L.; Huang, X. Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints 2020, 2020020221 (doi: 10.20944/preprints202002.0221.v1).

Abstract

ACE2, the putative receptor for the novel coronavirus (2019-nCoV), played an important role in cell entry of 2019-nCoV. However, it is not yet clear what cell types within the human body express ACE2. Here, a systematic analysis was undertaken using published single cell datasets. In total, our study analyzed 229652 cells, from five different organs, derived from 88 donors. The top ACE2 expressing cells include proximal tubule cells in the kidney and enterocytes in the intestine. Other major ACE2 expressing cells in the kidney include podocytes, intercalated cells and endothelial cells. Our results offer a comprehensive atlas of ACE2 expression at the single cell level and unravel the enormous potential targets of 2019-nCoVinfection beyond the lung.

Subject Areas

ACE2; single cell; 2019-nCoV

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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