Version 1
: Received: 15 February 2020 / Approved: 16 February 2020 / Online: 16 February 2020 (14:56:57 CET)
How to cite:
Zhu, Y.; Jiang, M.; Gao, L.; Huang, X. Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints2020, 2020020221. https://doi.org/10.20944/preprints202002.0221.v1
Zhu, Y.; Jiang, M.; Gao, L.; Huang, X. Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints 2020, 2020020221. https://doi.org/10.20944/preprints202002.0221.v1
Zhu, Y.; Jiang, M.; Gao, L.; Huang, X. Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints2020, 2020020221. https://doi.org/10.20944/preprints202002.0221.v1
APA Style
Zhu, Y., Jiang, M., Gao, L., & Huang, X. (2020). Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV. Preprints. https://doi.org/10.20944/preprints202002.0221.v1
Chicago/Turabian Style
Zhu, Y., Liang Gao and Xiaoyun Huang. 2020 "Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV" Preprints. https://doi.org/10.20944/preprints202002.0221.v1
Abstract
ACE2, the putative receptor for the novel coronavirus (2019-nCoV), played an important role in cell entry of 2019-nCoV. However, it is not yet clear what cell types within the human body express ACE2. Here, a systematic analysis was undertaken using published single cell datasets. In total, our study analyzed 229652 cells, from five different organs, derived from 88 donors. The top ACE2 expressing cells include proximal tubule cells in the kidney and enterocytes in the intestine. Other major ACE2 expressing cells in the kidney include podocytes, intercalated cells and endothelial cells. Our results offer a comprehensive atlas of ACE2 expression at the single cell level and unravel the enormous potential targets of 2019-nCoVinfection beyond the lung.
Keywords
ACE2; single cell; 2019-nCoV
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
