Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Pulmonary Pathology of Early Phase SARS-COV-2 Pneumonia

Version 1 : Received: 15 February 2020 / Approved: 16 February 2020 / Online: 16 February 2020 (14:41:28 CET)
Version 2 : Received: 27 February 2020 / Approved: 2 March 2020 / Online: 2 March 2020 (01:34:58 CET)

A peer-reviewed article of this Preprint also exists.

Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer, Journal of Thoracic Oncology (2020), doi: https://doi.org/10.1016/j.jtho.2020.02.010. Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer, Journal of Thoracic Oncology (2020), doi: https://doi.org/10.1016/j.jtho.2020.02.010.

Journal reference: Journal of Thoracic Oncology 2020
DOI: 10.1016/j.jtho.2020.02.010

Abstract

There is currently a lack of pathologic data on the SARS-CoV-2 pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate with globules, focal hyperplasia of pneumocytes with only patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

Subject Areas

coronavirus; COVID-19 pneumonia; pathology; SARS-CoV-2

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