Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

p-Hydroxybenzoic Acid beta-D-Glucosyl Ester and Cimidahurinine with Antimelanogenesis and Antioxidant Effects from Pyracantha angustifolia via Bioactivity-Guided Fractionation

Version 1 : Received: 14 February 2020 / Approved: 15 February 2020 / Online: 15 February 2020 (15:21:13 CET)

A peer-reviewed article of this Preprint also exists.

Shim, S.-Y.; Lee, Y.E.; Song, H.Y.; Lee, M. p-Hydroxybenzoic Acid β-d-Glucosyl Ester and Cimidahurinine with Antimelanogenesis and Antioxidant Effects from Pyracantha angustifolia via Bioactivity-Guided Fractionation. Antioxidants 2020, 9, 258. Shim, S.-Y.; Lee, Y.E.; Song, H.Y.; Lee, M. p-Hydroxybenzoic Acid β-d-Glucosyl Ester and Cimidahurinine with Antimelanogenesis and Antioxidant Effects from Pyracantha angustifolia via Bioactivity-Guided Fractionation. Antioxidants 2020, 9, 258.

Journal reference: Antioxidants 2020, 9, 258
DOI: 10.3390/antiox9030258

Abstract

Pyracantha angustifolia has been used in traditional medicine to treat a range of diseases of the stomach and improve digestion, blood circulation, diarrhea, dysentery, and hemostasis. This study evaluated bioactivity-guided fractionation as a means to identify therapeutic phytochemicals from P. angustifolia that can attenuate melanogenesis and oxidation. Seven compounds with inhibitory effects on melanin production and tyrosinase (TYR) activity, as well as ABTS and DPPH radical scavenging activities, and have not been reported as whitening materials, were isolated from the n-butanol fraction from P. angustifolia leaves (PAL). Among the seven compounds, p-hydroxybenzoic acid beta-d-glucosylester (HG), and cimidahurinine (CD) had strong inhibitory effects of melanin production, TYR activity, and ABTS and DPPH radical scavenging activities. Western blot analysis showed that HG and CD suppressed tyrosinase-related protein (TYRP)-1 and TYRP-2 expression. These results suggest that P. angustifolia containing active compounds, such as HG and CH, is a potent therapeutic candidate for the development of hypopigmenting agents.

Subject Areas

Pyracantha angustifolia; p-Hydroxybenzoic acid beta-D-glucosylester; Cimidahurinine; melanin; tyrosinase; antioxidant

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