Design of an Epitope-Based Synthetic Long Peptide Vaccine to Counteract the Novel China Coronavirus (2019-nCoV)

Florina Bojin; Oana Gavriliuc; Michael-Bogdan Margineanu; Virgil Paunescu

Working Paper Brief Report Version 1 This version is not peer-reviewed

Version 1 : Received: 6 February 2020 / Approved: 8 February 2020 / Online: 8 February 2020 (05:56:31 CET)

In this report, we demonstrate that it is possible to design epitope-based peptide vaccine candidates to counteract the novel China coronavirus (2019-nCoV) by using an approach similar to the one used in cancer neoantigen vaccination therapy. We identified multiepitope peptide vaccine candidates against 2019-nCov that can potentially trigger both CD4⁺ and CD8⁺ T cell immune response with increased efficiency due to the presence of CD4⁺ and CD8⁺ T cell epitopes and a cathepsin-sensitive linker. Furthermore, we suggest that the peptide design strategy should incorporate population-specific HLA alleles in order to optimize binding specificity of the peptides. We refer to this as populationalized vaccinomics.

2019-nCoV; coronavirus; peptide vaccine; CD4+ epitope; CD8+ epitope

Biology and Life Sciences, Immunology and Microbiology

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Design of an Epitope-Based Synthetic Long Peptide Vaccine to Counteract the Novel China Coronavirus (2019-nCoV)

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