Version 1
: Received: 3 January 2020 / Approved: 5 January 2020 / Online: 5 January 2020 (15:16:56 CET)
How to cite:
Huang, Y.; Cheng, K.; Yang, P.; Lin, M.; Huang, P.; Kuo, S.; Lee, J. Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints2020, 2020010037
Huang, Y.; Cheng, K.; Yang, P.; Lin, M.; Huang, P.; Kuo, S.; Lee, J. Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints 2020, 2020010037
Huang, Y.; Cheng, K.; Yang, P.; Lin, M.; Huang, P.; Kuo, S.; Lee, J. Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints2020, 2020010037
APA Style
Huang, Y., Cheng, K., Yang, P., Lin, M., Huang, P., Kuo, S., & Lee, J. (2020). Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints. https://doi.org/
Chicago/Turabian Style
Huang, Y., Sunn-We Kuo and Jang-Ming Lee. 2020 "Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT)" Preprints. https://doi.org/
Abstract
Photodynamic therapy has been applied endoscopically to treat early esophageal cancer. However, the long-term survival outcome of this treatment option is unknown in literature. Patients and Method: The patients of early esophageal cancer (clinical stage I) treated with photophrin based photodynamic therapy were analyzed for their long-term survival outcome and compared to those patients undergoing esophagectomy by a single surgeon for stage I disease. Results: There were 15 and 16 patients undergoing PDT and esophagectomy enrolled in the current study respectively. Complete response was achieved in 10 (66.7%) patients after PDT. After adjuvant chemoradiation (CCRT) complete response was achieved in 13 patients (86%). There is no mortality after PDT. Severe complication was detected in 3 patients including trachea-esophageal fistulae, esophageal stenosis and skin photosensitivity respectively. With a median follow-up duration of 110.2 months (+9.6 months) for the patients after PDT, there were 4 and 3 recurrence in the primary tumor site and regional lymph node respectively with 73.3% of successful local control rate of the primary tumor. There were 7 (46.7%) patients died during clinical follow-up of this cohort with 5 (33.3%) from disease progression of esophageal cancer and two from other diseases respectively. The five-year survival rate after PDT is 64.3%, whereas 70.9% of the patients after esophagectomy without significant difference of these two group of patients (P=0.72). Conclusion: Our preliminary results suggested that PDT might provide an equivalent long-term oncological outcome as compared to that done by esophagectomy for early esophageal cancer. A prospective randomized clinical trial comparing the results with esophagectomy and other endoscopic abrasive therapies is warrant in the future.
Keywords
photodynamic therapy for esophageal cancer
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
