Working Paper Article Version 1 This version is not peer-reviewed

Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT)

Version 1 : Received: 3 January 2020 / Approved: 5 January 2020 / Online: 5 January 2020 (15:16:56 CET)

How to cite: Huang, Y.; Cheng, K.; Yang, P.; Lin, M.; Huang, P.; Kuo, S.; Lee, J. Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints 2020, 2020010037 Huang, Y.; Cheng, K.; Yang, P.; Lin, M.; Huang, P.; Kuo, S.; Lee, J. Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT). Preprints 2020, 2020010037

Abstract

Photodynamic therapy has been applied endoscopically to treat early esophageal cancer. However, the long-term survival outcome of this treatment option is unknown in literature. Patients and Method: The patients of early esophageal cancer (clinical stage I) treated with photophrin based photodynamic therapy were analyzed for their long-term survival outcome and compared to those patients undergoing esophagectomy by a single surgeon for stage I disease. Results: There were 15 and 16 patients undergoing PDT and esophagectomy enrolled in the current study respectively. Complete response was achieved in 10 (66.7%) patients after PDT. After adjuvant chemoradiation (CCRT) complete response was achieved in 13 patients (86%). There is no mortality after PDT. Severe complication was detected in 3 patients including trachea-esophageal fistulae, esophageal stenosis and skin photosensitivity respectively. With a median follow-up duration of 110.2 months (+9.6 months) for the patients after PDT, there were 4 and 3 recurrence in the primary tumor site and regional lymph node respectively with 73.3% of successful local control rate of the primary tumor. There were 7 (46.7%) patients died during clinical follow-up of this cohort with 5 (33.3%) from disease progression of esophageal cancer and two from other diseases respectively. The five-year survival rate after PDT is 64.3%, whereas 70.9% of the patients after esophagectomy without significant difference of these two group of patients (P=0.72). Conclusion: Our preliminary results suggested that PDT might provide an equivalent long-term oncological outcome as compared to that done by esophagectomy for early esophageal cancer. A prospective randomized clinical trial comparing the results with esophagectomy and other endoscopic abrasive therapies is warrant in the future.

Subject Areas

photodynamic therapy for esophageal cancer

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