Version 1
: Received: 25 December 2019 / Approved: 26 December 2019 / Online: 26 December 2019 (12:37:36 CET)
How to cite:
Smesam, H.; Qazmooz, H.; Arjmand, S.; Al-Hakeim, H.K.; Ranaei‐Siadat,, S.O. Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients. Preprints2019, 2019120356. https://doi.org/10.20944/preprints201912.0356.v1
Smesam, H.; Qazmooz, H.; Arjmand, S.; Al-Hakeim, H.K.; Ranaei‐Siadat,, S.O. Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients. Preprints 2019, 2019120356. https://doi.org/10.20944/preprints201912.0356.v1
Smesam, H.; Qazmooz, H.; Arjmand, S.; Al-Hakeim, H.K.; Ranaei‐Siadat,, S.O. Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients. Preprints2019, 2019120356. https://doi.org/10.20944/preprints201912.0356.v1
APA Style
Smesam, H., Qazmooz, H., Arjmand, S., Al-Hakeim, H.K., & Ranaei‐Siadat,, S.O. (2019). Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients. Preprints. https://doi.org/10.20944/preprints201912.0356.v1
Chicago/Turabian Style
Smesam, H., Hussein Kadhem Al-Hakeim and Seyed Omid Ranaei‐Siadat,. 2019 "Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients" Preprints. https://doi.org/10.20944/preprints201912.0356.v1
Abstract
Beta thalassemia major (β-TM) disorder characterized by the lack, or severe reduction in the production of hemoglobin β-globin chains. The standard protocol for the management of β-TM is blood transfusion and iron chelation therapy to reduce the iron overload state. The present study aimed to investigate the relationships between two iron regulatory hormones, hepcidin (HEPC) and erythroferrone (ERFE) levels and iron status parameters (ISPs) in Iraqi patients with β-TM. ISPs and hormones were measured in sixty patients and compared with thirty healthy controls. The results indicated significant changes in different iron status parameters, while ferritin (FRT) with the ~11 fold increase showed the most change. Significant reduction in HEPC and increase in ERFE levels were detected in patients as compared to the control group, while no direct correlation was identified with the other measured ISPs. Receiver operating characteristic (ROC) analysis showed that the z-score of the composite of ERFE+FRT has a full diagnostic ability for β-TM. In conclusion, our finding indicated the correlation between different ISPs, FRT as the leading predictor of iron overload and tow main iron regulatory hormones.
Keywords
Beta-thalassemia, Erythroferrone, Ferritin, Hepcidin, Iron overload
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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