Version 1
: Received: 21 December 2019 / Approved: 22 December 2019 / Online: 22 December 2019 (13:16:16 CET)
How to cite:
von Linstow, C.U.; DeLano-Taylor, M.; Kordower, J.H.; Brundin, P. Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?. Preprints2019, 2019120296
von Linstow, C.U.; DeLano-Taylor, M.; Kordower, J.H.; Brundin, P. Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?. Preprints 2019, 2019120296
von Linstow, C.U.; DeLano-Taylor, M.; Kordower, J.H.; Brundin, P. Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?. Preprints2019, 2019120296
APA Style
von Linstow, C.U., DeLano-Taylor, M., Kordower, J.H., & Brundin, P. (2019). Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?. Preprints. https://doi.org/
Chicago/Turabian Style
von Linstow, C.U., Jeffrey H. Kordower and Patrik Brundin. 2019 "Does Developmental Variability in the Number of Midbrain Dopamine Neurons Affect Individual Risk for Sporadic Parkinson’s Disease?" Preprints. https://doi.org/
Abstract
Parkinson’s disease (PD) is a slowly progressing neurodegenerative disorder that is coupled to both widespread protein aggregation and to loss of substantia nigra dopamine (DA) neurons, resulting in a wide variety of motor and non-motor signs and symptoms. Recent findings suggest that the PD process is triggered several years before there is sufficient degeneration of DA neurons to cause onset of overt motor symptoms. According to this concept, the number of DA neurons present in the substantia nigra at birth could influence the time from the molecular triggering event until the clinical diagnosis with lower number of neurons at birth increasing the risk to develop the disease. Conversely, the risk for diagnosis would be reduced if the number of DA neurons is high at birth. In this commentary, we discuss the genetic and epigenetic factors that might influence the number of nigral DA neurons that each individual is born with and how these may be linked to PD risk.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
