Working Paper Short Note Version 1 This version is not peer-reviewed

Orthogonal Pores and Boolean Logic

Version 1 : Received: 27 November 2019 / Approved: 28 November 2019 / Online: 28 November 2019 (09:55:40 CET)

How to cite: Sampath, G. Orthogonal Pores and Boolean Logic. Preprints 2019, 2019110359 Sampath, G. Orthogonal Pores and Boolean Logic. Preprints 2019, 2019110359


An orthogonal pore ('orthopore') is conceptually based on an electrolytic cell with a standard pore (the main or 'longitudinal' pore) between cis and trans compartments filled with electrolyte and augmented by a secondary or 'transverse' pore in the form of a channel that is perpendicular to and intersects the main pore. Orthopores can be designed at different scales: macro through micro to nano. With nano-sized pores an analyte (polymer) can be threaded through the main pore and exposed at the junction to electrolyte flow through the secondary pore. Polymer translocation speeds are then independent of the current measured, which can be of an arbitrary magnitude even with the polymer stationary. Orthopores have a wide range of potential applications, including polymer (DNA and protein) sequencing, DNA unzipping, logic circuitry, and protein identification. The present report shows how orthopores can be used to implement boolean logic.


boolean logic; nanopores; logic gates; electrolytic cell; NAND gate; NOR gate


Biology and Life Sciences, Biology and Biotechnology

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