Preprint Article Version 1 This version is not peer-reviewed

Serum Apelin and Galactin-3 in Preeclampsia in Iraq

Version 1 : Received: 21 October 2019 / Approved: 23 October 2019 / Online: 23 October 2019 (17:31:26 CEST)

How to cite: Taha, A.S.; Zahraei, Z.; Al-Hakeim, H. Serum Apelin and Galactin-3 in Preeclampsia in Iraq. Preprints 2019, 2019100270 (doi: 10.20944/preprints201910.0270.v1). Taha, A.S.; Zahraei, Z.; Al-Hakeim, H. Serum Apelin and Galactin-3 in Preeclampsia in Iraq. Preprints 2019, 2019100270 (doi: 10.20944/preprints201910.0270.v1).

Abstract

Preeclampsia (PE) is a common pregnancy complication. It is associated with high maternal morbidity and mortality rates and intrauterine foetal growth restriction. This condition is characterised by high blood pressure and urinary protein levels. Apelin and galectin-3 (Gal- 3) are peptides involved in the regulation of body fluid homeostasis, inflammation and cardiovascular functions. This study aimed to determine the correlations amongst serum apelin and Gal-3 levels and insulin resistance (IR) in women with PE. Sixty patients with PE and 30 healthy controls participated in this study. The PE group had significantly lower apelin levels (p < 0.01) and higher Gal-3 levels (p < 0.05) than the control group. The PE group had higher serum glucose levels and β-cell functions than the control group. Moreover, patients with PE exhibited dyslipidaemia. Correlation analysis indicated that apelin and Gal-3 levels were not significantly correlated. Moreover, no correlation existed between the apelin levels and any measured parameters of the PE group. In conclusion, the elevations in serum Gal-3 levels with increments in IR-related parameters and lipid profiles reflect the possible contribution of Gal-3 to the harmful effects of IR and dyslipidemia levels on women with PE.

Subject Areas

apelin; galectin-3; Preeclampsia; insulin resistance; lipid profile

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