Preprint Review Version 1 This version is not peer-reviewed

Parenteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis and Meta-Regression

Version 1 : Received: 17 October 2019 / Approved: 18 October 2019 / Online: 18 October 2019 (11:36:07 CEST)

How to cite: Comeche, J.M.; Comino, I.; Atavilla, C.; Tuells, J.; Gutierrez-Hervas, A.; Caballero, P. Parenteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis and Meta-Regression. Preprints 2019, 2019100214 (doi: 10.20944/preprints201910.0214.v1). Comeche, J.M.; Comino, I.; Atavilla, C.; Tuells, J.; Gutierrez-Hervas, A.; Caballero, P. Parenteral Nutrition in Patients with Inflammatory Bowel Disease. Systematic Review, Meta-Analysis and Meta-Regression. Preprints 2019, 2019100214 (doi: 10.20944/preprints201910.0214.v1).

Abstract

Inflammatory bowel disease (IBD) is a chronic disease mediated by the immune system and characterized by the inflammation of the gastrointestinal tract. This study is to understand how the use of parenteral nutrition (PN) can affect the adult population diagnosed with IBD. We conducted a systematic review, meta-analysis and a meta-regression. On the different databases, (MEDLINE, Scopus, Cochrane, LILACS, CINAHL, WOS) we found 119 registers, the accuracy was 16% (19 registers); After a Full-text review, only 15 research studies were selected for qualitative synthesis and 10 for Meta-analysis and Meta-regression. The variables used were Crohn’s Disease Activity Index (CDAI), albumin, body weight (BW) and post-operative complications (COM). PN has shown to have efficacy for the treatment of IBD and is compatible with other medicines. The CDAI and albumin improve although the effect of PN are greater after a while. However, the effect on the albumin could be less than the observed value in the meta-analysis, due to a possible publication bias. The BW does not change after intervention. COM utilizing PN has been observed, although the proportion is low.

Subject Areas

inflammatory bowel diseases; parenteral nutrition; systematic review; meta-analysis; crohn disease

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