Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents

Petter I. Andersen; Aleksandr Ianevski; Hilde Lysvand; Astra Vitkauskiene; Valentyn Oksenych; Magnar Bjoras; Kaidi Telling; Irja Lutsar; Uga Dumpis; Yasuhiko Irie; Tanel Tenson; Anu Kantele; Denis E. Kainov

doi:10.20944/preprints201910.0144.v3

Preprint Review Version 3 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 12 October 2019 / Approved: 13 October 2019 / Online: 13 October 2019 (15:22:27 CEST)
Version 2 : Received: 7 November 2019 / Approved: 7 November 2019 / Online: 7 November 2019 (14:59:43 CET)
Version 3 : Received: 26 December 2019 / Approved: 27 December 2019 / Online: 27 December 2019 (03:35:32 CET)
Version 4 : Received: 27 January 2020 / Approved: 27 January 2020 / Online: 27 January 2020 (02:09:09 CET)
Version 5 : Received: 7 February 2020 / Approved: 10 February 2020 / Online: 10 February 2020 (09:55:44 CET)
Version 6 : Received: 12 February 2020 / Approved: 14 February 2020 / Online: 14 February 2020 (02:27:24 CET)

Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs) could provide additional protection of general population from emerging and re-emerging viral diseases reinforcing the arsenal of available antiviral options. Here, we reviewed development process of BSAAs and summarized the information on 119 safe-in-man agents in freely accessible database (https://drugvirus.info/). The number of BSAAs will be increased, their developmental status will be updated, spectrum of their indications will be expanded, as well as BSAA combinations will be approved pending the results of further pre-clinical and clinical studies.

virus; antiviral drug; drug discovery; drug development; broad-spectrum antivirals

Biology and Life Sciences, Virology

Comment 1

Received: 27 December 2019
Commenter: Denis Kainov
Commenter's Conflict of Interests: Author

Comment: We introduced changes in the preprint following referees' comments.

+ Respond to this comment

Not displayed online.

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

* All users must log in before leaving a comment

Notify me about updates to this article or when a peer-reviewed version is published.

Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents

Abstract

Keywords

Subject

Comments (1)