Review
Version 1
Preserved in Portico This version is not peer-reviewed
Role of miRNAs In Bone Homeostasis - A Short Review
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Version 1
: Received: 3 October 2019 / Approved: 4 October 2019 / Online: 4 October 2019 (11:38:23 CEST)
How to cite: Ghafoor, M.; Sumrin, A. Role of miRNAs In Bone Homeostasis - A Short Review. Preprints 2019, 2019100048. https://doi.org/10.20944/preprints201910.0048.v1 Ghafoor, M.; Sumrin, A. Role of miRNAs In Bone Homeostasis - A Short Review. Preprints 2019, 2019100048. https://doi.org/10.20944/preprints201910.0048.v1
Abstract
Bone homeostasis depends on the interplay between bone resporption by osteoclasts and bone formation by osteoblasts. Any Imbalance of this tightly regulated process can cause diseases such as osteoporosis. Therefore, the knowledge about the factors that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass density and deterioration of bone tissue. Mature miRNAs are about 22 nucleotide long non coding RNA molecules that are involved in regulatory processes intracellularly. A number of scientific studies have revealed a comprehensive and evidential knowledge about miRNAs that affect the bone metabolism by influencing bone formation and resorption processes. In this short review we have summrized the regulatory role of some selective miRNAs in bone formation.
Keywords
mirna; osteoblast; osteoclsat
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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