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A Complex Systems Analysis of Cancer Networks
: Received: 25 September 2019 / Approved: 27 September 2019 / Online: 27 September 2019 (07:24:43 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Complex Systems 2020, 29
Cancers remain the lead cause of disease-related, pediatric death in North America. The emerging field of complex systems has redefined cancer networks as a computational system with intractable algorithmic complexity. Herein, a tumor and its heterogeneous phenotypes are discussed as dynamical systems having multiple, strange attractors. Machine learning, network science and algorithmic information dynamics are discussed as current tools for cancer network reconstruction. Deep Learning architectures and computational fluid models are proposed for better forecasting gene expression patterns in cancer ecosystems. Cancer cell decision-making is investigated within the framework of complex systems and complexity theory.
Supplementary and Associated Material
cancer; complexity; machine learning; deep learning; fluid dynamics; turbulence; chaos
MEDICINE & PHARMACOLOGY, Oncology & Oncogenics
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