Version 1
: Received: 28 August 2019 / Approved: 29 August 2019 / Online: 29 August 2019 (17:22:42 CEST)
How to cite:
Agin, M.; Kayar, Y. Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement. Preprints2019, 2019080314. https://doi.org/10.20944/preprints201908.0314.v1
Agin, M.; Kayar, Y. Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement. Preprints 2019, 2019080314. https://doi.org/10.20944/preprints201908.0314.v1
Agin, M.; Kayar, Y. Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement. Preprints2019, 2019080314. https://doi.org/10.20944/preprints201908.0314.v1
APA Style
Agin, M., & Kayar, Y. (2019). Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement. Preprints. https://doi.org/10.20944/preprints201908.0314.v1
Chicago/Turabian Style
Agin, M. and Yusuf Kayar. 2019 "Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement" Preprints. https://doi.org/10.20944/preprints201908.0314.v1
Abstract
Background and Objective: In the present study, the purpose was to compare the demographic, clinical and laboratory results of pediatric brucella cases who had liver involvement and who had no specific organ involvement. Material and Methods: The data of 248 patients between 2 and 18 years of age diagnosed with Brucellosis between July 2017 and August 2018 were analyzed retrospectively. The patients who had liver involvement and who did not have other specific organ involvement were compared in terms of presentation, physical examination findings, age, gender, hemogram, AST, ALT, GGT, ALP, bilirubines, sedimentation, CRP, clinical and laboratory findings, and culture and relapse rates. Results: No significant differences were detected between the patients who had liver involvement (n=92) and who did not have specific organ involvement (n=156) in terms of diagnosis age and gender. Loss of appetite, nausea and sensitive stomach were higher in the patients who had hepatic involvement, and weariness was determined to be more in the control group patients. In the patients who had hepatic involvement, the hemoglobin and platelet values were lower, and the sedimentation, CRP and blood culture growth were higher. The relapse rates were lower in patients who had liver involvement. Conclusion: In patients who have liver involvement, in addition to elevated hepatomegaly and transaminase levels, the growth rate of the acute-phase reactants and brucella is higher in blood culture; and the relapse rate is lower after treatment. Brucellosis must be considered in the differential diagnosis of hepatomegaly and transaminase elevation where brucellosis is seen endemically. We believe that early diagnosis of brucellosis is important in treatment response.
Keywords
brucellosis; elevated liver enzymes; hepatomegaly; children
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
