Article
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This version is not peer-reviewed
Statistical Methods for Computer Experiments with Applications in Neuroscience
Gilad Shapira
Version 1
: Received: 21 August 2019 / Approved: 23 August 2019 / Online: 23 August 2019 (11:27:23 CEST)
How to cite: Shapira, G.; Shaposhnik, E.; Steinberg, D.M. Statistical Methods for Computer Experiments with Applications in Neuroscience. Preprints 2019, 2019080246 (doi: 10.20944/preprints201908.0246.v1). Shapira, G.; Shaposhnik, E.; Steinberg, D.M. Statistical Methods for Computer Experiments with Applications in Neuroscience. Preprints 2019, 2019080246 (doi: 10.20944/preprints201908.0246.v1).
Abstract
Many scientific and technological problems are studied with the help of computer codes that simulate the phenomena of interest rather than via traditional laboratory experiments. Such models play an important role in neuroscience where they are used to mimic brain function from the sub-cellular to the macroscopic level. Exploration with computer models carries with it a number of statistical challenges: where to sample the input space for the simulator, how to make sense of the data that is generated, how to estimate unknown parameters in the model, how to validate a model. The simulator setting also has some unique problems and possibilities. This review paper describes statistical research on these issues and how that work might be applied to neural simulations.
Subject Areas
statistics; in silico experiments; neural simulation; gaussian process regression; Bayesian inference
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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