Preprint Article Version 2 This version is not peer-reviewed

The ZIKA Virus Delays Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins

Version 1 : Received: 13 August 2019 / Approved: 15 August 2019 / Online: 15 August 2019 (07:39:04 CEST)
Version 2 : Received: 16 September 2019 / Approved: 18 September 2019 / Online: 18 September 2019 (03:05:26 CEST)

A peer-reviewed article of this Preprint also exists.

Turpin, J.; Frumence, E.; Desprès, P.; Viranaicken, W.; Krejbich-Trotot, P. The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins. Cells 2019, 8, 1338. Turpin, J.; Frumence, E.; Desprès, P.; Viranaicken, W.; Krejbich-Trotot, P. The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins. Cells 2019, 8, 1338.

Journal reference: Cells 2019, 8, 1338
DOI: 10.3390/cells8111338

Abstract

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction of cell death. However, previous studies suggest that the virally-induced apoptosis occurs at a slower rate compared to the course of viral production. In this present study, we investigated the capacity of ZIKV to delay host cell apoptosis. We provide evidence that ZIKV has the ability to interfere with apoptosis whether it is intrinsically or extrinsically induced. In cells expressing viral replicon-type constructions, we show that this control is achieved through replication. Finally, our work highlights an important role for anti-apoptotic Bcl-2 family protein in the ability of ZIKV to control apoptotic pathways, avoiding premature cell death and thereby promoting virus replication in the host-cell.

Subject Areas

Zika virus; apoptosis; viral replication; Bcl-2 protein family

Comments (1)

Comment 1
Received: 18 September 2019
Commenter: Wildriss Viranaicken
Commenter's Conflict of Interests: Author
Comment: -
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