Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

The ZIKA Virus Delays Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins

Jonathan Turpin
,
Etienne Frumence
,
Philippe Desprès
ORCID logo ,
Wildriss Viranaïcken
* ORCID logo ,
Pascale Krejbich-Trotot
*
Version 1 : Received: 13 August 2019 / Approved: 15 August 2019 / Online: 15 August 2019 (07:39:04 CEST)
Version 2 : Received: 16 September 2019 / Approved: 18 September 2019 / Online: 18 September 2019 (03:05:26 CEST)

A peer-reviewed article of this Preprint also exists.

Turpin, J.; Frumence, E.; Desprès, P.; Viranaicken, W.; Krejbich-Trotot, P. The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins. Cells 2019, 8, 1338. Turpin, J.; Frumence, E.; Desprès, P.; Viranaicken, W.; Krejbich-Trotot, P. The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins. Cells 2019, 8, 1338.

Abstract

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to be associated with complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with induction of cell death. However, previous studies suggest that the virally-induced apoptosis occurs at a slower rate compared to the course of viral production. In this present study, we investigated the capacity of ZIKV to delay host cell apoptosis. We provide evidence that ZIKV has the ability to interfere with apoptosis whether it is intrinsically or extrinsically induced. In cells expressing viral replicon-type constructions, we show that this control is achieved through replication. Finally, our work highlights an important role for anti-apoptotic Bcl-2 family protein in the ability of ZIKV to control apoptotic pathways, avoiding premature cell death and thereby promoting virus replication in the host-cell.

Keywords

Zika virus; apoptosis; viral replication; Bcl-2 protein family

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1
Received: 18 September 2019
Commenter: Wildriss Viranaicken
Commenter's Conflict of Interests: Author
Comment: -
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