Working Paper Review Version 1 This version is not peer-reviewed

Non-Canonical Ion Channel Behaviour in Pain

Version 1 : Received: 7 August 2019 / Approved: 8 August 2019 / Online: 8 August 2019 (12:31:26 CEST)

A peer-reviewed article of this Preprint also exists.

Ciotu, C.I.; Tsantoulas, C.; Meents, J.; Lampert, A.; McMahon, S.B.; Ludwig, A.; Fischer, M.J. Noncanonical Ion Channel Behaviour in Pain. Int. J. Mol. Sci. 2019, 20, 4572. Ciotu, C.I.; Tsantoulas, C.; Meents, J.; Lampert, A.; McMahon, S.B.; Ludwig, A.; Fischer, M.J. Noncanonical Ion Channel Behaviour in Pain. Int. J. Mol. Sci. 2019, 20, 4572.

Abstract

Ion channels contribute fundamental properties to all cell membranes. The ion channels are highly diverse in conductivity, structure, location and function. However, many of them can be regulated by common mechanisms, such as voltage or (de-)phosphorylation. Considering primarily pain-related ion channels, this review covers more novel and less known features of ion channel function, also with the aim to transfer knowledge between fields, which get inevitably more separate due to their size.

Keywords

pharmacology; drug development; sodium channel; potassium channel; TRP channel; HCN channels

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

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