Version 1
: Received: 30 July 2019 / Approved: 31 July 2019 / Online: 31 July 2019 (04:45:51 CEST)
How to cite:
Limoli, P.G.; Vingolo, E.M.; Morales, M.U.; Limoli, C.; Nebbioso, M. Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review. Preprints2019, 2019070347. https://doi.org/10.20944/preprints201907.0347.v1
Limoli, P.G.; Vingolo, E.M.; Morales, M.U.; Limoli, C.; Nebbioso, M. Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review . Preprints 2019, 2019070347. https://doi.org/10.20944/preprints201907.0347.v1
Limoli, P.G.; Vingolo, E.M.; Morales, M.U.; Limoli, C.; Nebbioso, M. Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review. Preprints2019, 2019070347. https://doi.org/10.20944/preprints201907.0347.v1
APA Style
Limoli, P.G., Vingolo, E.M., Morales, M.U., Limoli, C., & Nebbioso, M. (2019). Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review<strong> </strong>. Preprints. https://doi.org/10.20944/preprints201907.0347.v1
Chicago/Turabian Style
Limoli, P.G., Celeste Limoli and Marcella Nebbioso. 2019 "Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study After Literature Review<strong> </strong>" Preprints. https://doi.org/10.20944/preprints201907.0347.v1
Abstract
To evaluate whether autologous mesenchymal cells, adipose derived stem cells and platelet-rich plasma, grafted into the supracoroideal space by surgical treatment according to Limoli retinal restoration technique (LRRT), can produce growth factors in order to exert a beneficial effect in retinitis pigmentosa (RP) patients. Twenty-one eyes underwent surgery and divided based on retinal foveal thickness ≤ 190 or >190 µm into group A and group B, respectively. The specific LRRT triad was grafted in a deep scleral pocket above the choroid of each eye. At 6-month follow-up, group B showed an improvement in residual close-up visus and sensitivity at microperimetry compared to group A. After an in-depth review of molecular biology studies concerning degenerative phenomena underlying the etiopathogenesis of RP, it can be confirmed that further research is needed on tapeto-retinal degenerations both from a clinical and molecular point of view to obtain better functional results. In particular, it is necessary to increase the number of patients, extend observation times, and treat subjects in the presence of still trophic retinal tissue to allow adequate biochemical and functional catering.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
