Preprint Article Version 1 This version is not peer-reviewed

Association of KCNJ11 Genetic Variations with Risk of Type 2 Diabetes Mellitus (T2DM) in North Indian Population

Version 1 : Received: 3 July 2019 / Approved: 5 July 2019 / Online: 5 July 2019 (04:53:09 CEST)

How to cite: Khan, V.; Bhatt, D.; Khan, S.; VERMA, A.K.; Hasan, R.; Rafat, S.; Goyal, Y.; Bharti, P.S.; Shareef, M.Y.; Alsahli, M.A.; Rahmani, A.H.; Dev, K. Association of KCNJ11 Genetic Variations with Risk of Type 2 Diabetes Mellitus (T2DM) in North Indian Population. Preprints 2019, 2019070089 (doi: 10.20944/preprints201907.0089.v1). Khan, V.; Bhatt, D.; Khan, S.; VERMA, A.K.; Hasan, R.; Rafat, S.; Goyal, Y.; Bharti, P.S.; Shareef, M.Y.; Alsahli, M.A.; Rahmani, A.H.; Dev, K. Association of KCNJ11 Genetic Variations with Risk of Type 2 Diabetes Mellitus (T2DM) in North Indian Population. Preprints 2019, 2019070089 (doi: 10.20944/preprints201907.0089.v1).

Abstract

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. Interaction between various genetic variants and environmental factors triggers T2DM. The main aim of this study was to find the risk associated with genetic variant (rs5210) of KCNJ11gene in the development of T2D in Indian Population. A total number of 300 cases of T2D and 100 control samples were studied to find the polymorphism in KCNJ11 through PCR-RFLP. The genotype and allele frequencies in T2DM cases were significantly different from the control population. We found a significant association of KCNJ11 (rs5210) gene polymorphism with T2DM in North Indian patients indicating the role of this variant in developing risk for T2DM.

Subject Areas

type 2 diabetes; KCNJ11; RFLP; SNP

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