Preprint Review Version 1 This version is not peer-reviewed

Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?

Version 1 : Received: 3 July 2019 / Approved: 4 July 2019 / Online: 4 July 2019 (13:19:51 CEST)

How to cite: Choi, S.; Kam, H.; Kim, K.; Park, S.I.; Lee, Y. Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?. Preprints 2019, 2019070081 (doi: 10.20944/preprints201907.0081.v1). Choi, S.; Kam, H.; Kim, K.; Park, S.I.; Lee, Y. Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?. Preprints 2019, 2019070081 (doi: 10.20944/preprints201907.0081.v1).

Abstract

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-dimensional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with poor prognosis, as well as treatment resistance whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as strategies for using HSP27 inhibitors for therapeutic purposes.

Subject Areas

Heat shock protein 27; HSP27 inhibitor; Anti-cancer drugs, Resistance

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