Preprint Review Version 1 This version is not peer-reviewed

Importance of the Androgen Receptor Signalling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis

Version 1 : Received: 1 July 2019 / Approved: 3 July 2019 / Online: 3 July 2019 (10:41:30 CEST)

How to cite: Edelsztein, N.Y.; Rey, R.A. Importance of the Androgen Receptor Signalling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis. Preprints 2019, 2019070061 (doi: 10.20944/preprints201907.0061.v1). Edelsztein, N.Y.; Rey, R.A. Importance of the Androgen Receptor Signalling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis. Preprints 2019, 2019070061 (doi: 10.20944/preprints201907.0061.v1).

Abstract

Androgens are key for pubertal development of the mammalian testis, a phenomenon tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signalling affects Sertoli cell function and morphology by concomitantly inhibiting some processes and promoting others that contribute jointly to the completion of spermatogenesis. We focus on the molecular mechanisms that underlie AMH inhibition by androgens at puberty, as well as on the role androgens have on Sertoli cell tight junction formation and maintenance and, consequently, on its effect on proper germ cell differentiation and meiotic onset during spermatogenesis.

Subject Areas

Sertoli; meiosis; AMH; blood-testis barrier; spermatogenesis

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