Preprint Review Version 1 This version is not peer-reviewed

Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases

Version 1 : Received: 14 June 2019 / Approved: 18 June 2019 / Online: 18 June 2019 (13:07:49 CEST)

How to cite: Rana, P.; Franco, E.F.; Rao, Y.; Syed, K.; Barh, D.; Azevedo, V.; Ramos, R.T.J.; Ghosh, P. Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases. Preprints 2019, 2019060178 (doi: 10.20944/preprints201906.0178.v1). Rana, P.; Franco, E.F.; Rao, Y.; Syed, K.; Barh, D.; Azevedo, V.; Ramos, R.T.J.; Ghosh, P. Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases. Preprints 2019, 2019060178 (doi: 10.20944/preprints201906.0178.v1).

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between these two diseases is still unknown. In this paper, we analyzed how these diseases relate to each other from a genomics viewpoint. Using an extensive literature search, we accumulated the list of genes from the major genome-wide association (GWAS) studies. However, we found only one gene (HLA-DRB5) reported in these GWAS studies that are common between AD and PD. We also listed all the miRNAs that have been previously reported for AD and PD. Here we found 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene coexpression network for both AD and PD. Network analysis on these networks show six clusters of genes related to AD and four clusters of genes related to PD.

Subject Areas

Alzheimer's disease; Parkinson's disease; genetics; gene regulatory network; miRNAs

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