Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases

Pratip Rana
* ORCID logo ,
Edian F. Franco
ORCID logo ,
Yug Rao
,
Khajamoinuddin Syed
,
Debmalya Barh
ORCID logo ,
Vasco Azevedo
ORCID logo ,
Rommel T. J. Ramos
,
Preetam Ghosh
Version 1 : Received: 14 June 2019 / Approved: 18 June 2019 / Online: 18 June 2019 (13:07:49 CEST)

A peer-reviewed article of this Preprint also exists.

Rana, P.; Franco, E.F.; Rao, Y.; Syed, K.; Barh, D.; Azevedo, V.; Ramos, R.T.J.; Ghosh, P. Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases. Int. J. Mol. Sci. 2019, 20, 3730. Rana, P.; Franco, E.F.; Rao, Y.; Syed, K.; Barh, D.; Azevedo, V.; Ramos, R.T.J.; Ghosh, P. Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases. Int. J. Mol. Sci. 2019, 20, 3730.

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between these two diseases is still unknown. In this paper, we analyzed how these diseases relate to each other from a genomics viewpoint. Using an extensive literature search, we accumulated the list of genes from the major genome-wide association (GWAS) studies. However, we found only one gene (HLA-DRB5) reported in these GWAS studies that are common between AD and PD. We also listed all the miRNAs that have been previously reported for AD and PD. Here we found 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene coexpression network for both AD and PD. Network analysis on these networks show six clusters of genes related to AD and four clusters of genes related to PD.

Keywords

Alzheimer's disease; Parkinson's disease; genetics; gene regulatory network; miRNAs

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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