Review
Version 1
This version is not peer-reviewed
Therapeutic Effect of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury
Version 1
: Received: 6 June 2019 / Approved: 11 June 2019 / Online: 11 June 2019 (04:28:04 CEST)
How to cite: Oliva, J. Therapeutic Effect of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury. Preprints 2019, 2019060083 Oliva, J. Therapeutic Effect of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury. Preprints 2019, 2019060083
Abstract
The shortage of donor organs is a major global concern. Organ failure requires the transplantation of functional organs. Organ donors are preserved in warm or cold ischemia. Ischemia and reperfusion damage the organs, due to the lack of oxygen during the ischemia step and the oxidative stress during the reperfusion step. Different methodologies were developed to prevent or diminish the level of injuries. Preservation solutions were first developed, followed by the addition of chemical compounds. In addition of inhibitors of mitogen activated protein kinase, inhibitors of the proteasome, mesenchymal stem cells started to be used 13 years ago to prevent or diminish the organ’s injuries. Mesenchymal stem cells (e.g bone marrow stem cells, adipose derived stem cells) have proven to be powerful tools in repairing damaged organs. This review will focus on the use of some bone marrow stem cells, adipose derived stem cells and umbilical cord stem cells on preventing or decreasing the injuries due to ischemia-reperfusion.
Keywords
ischemia-reperfusion injury; mesenchymal stem cells; treatment
Subject
Medicine and Pharmacology, Transplantation
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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