Version 1
: Received: 4 June 2019 / Approved: 5 June 2019 / Online: 5 June 2019 (14:53:35 CEST)
Version 2
: Received: 25 July 2019 / Approved: 27 July 2019 / Online: 27 July 2019 (08:40:12 CEST)
How to cite:
Melrose, J. The Glucosinolates, A Sulphur Glucoside Family of Mustard
Phytochemicals With Diverse Biomedical Application. Preprints2019, 2019060042. https://doi.org/10.20944/preprints201906.0042.v1
Melrose, J. The Glucosinolates, A Sulphur Glucoside Family of Mustard
Phytochemicals With Diverse Biomedical Application. Preprints 2019, 2019060042. https://doi.org/10.20944/preprints201906.0042.v1
Melrose, J. The Glucosinolates, A Sulphur Glucoside Family of Mustard
Phytochemicals With Diverse Biomedical Application. Preprints2019, 2019060042. https://doi.org/10.20944/preprints201906.0042.v1
APA Style
Melrose, J. (2019). The Glucosinolates, A Sulphur Glucoside Family of Mustard
Phytochemicals With Diverse Biomedical Application. Preprints. https://doi.org/10.20944/preprints201906.0042.v1
Chicago/Turabian Style
Melrose, J. 2019 "The Glucosinolates, A Sulphur Glucoside Family of Mustard
Phytochemicals With Diverse Biomedical Application" Preprints. https://doi.org/10.20944/preprints201906.0042.v1
Abstract
This study reviewed aspects of the biology of two members of the glucosinolate family, namely sinigrin and glucoraphanin and their potential biomedical therapeutic and industrial applications. Sinigrin and glucoraphanin are converted by the -sulphoglucosidase myrosinase or the gut microbiota into their bioactive forms, allyl isothiocyanate (AITC) and sulphoraphanin (SFN) which constitute part of a sophisticated defence mechanism plants have developed over several hundred million years of evolution to protect them from parasitic attack from aphids, ticks and nematodes. These compounds display biological activities in a number of mammalian physiological processes and potential biotherapeutic application. Glucosinolates may be useful in bio-fumigation and treatment of biofilms which occur on plant equipment and medical implants formed by problematic pathogenic bacteria such as Pseudomonas aeruginosa. AITC and SFN display similar antibiotic activity as Vancomycin in the treatment of bacteria listed by the World Health Organization as antibiotic-resistant "priority pathogens".AITC and SFN also display bioactivity in cancer chemoprevention through the induction of phase II antioxidant enzymes which inactivate potential carcinogens. The glucosinolates have found application in the prevention of bacterial and fungal spoilage of food substances during processing and in advanced food packaging formats which improve the shelf-life of food products.
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
