PreprintCase ReportVersion 1Preserved in Portico This version is not peer-reviewed
Molecular Characterization of a Long Term Survivor Double Metastatic Non Small Sell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy
Brunetti, O.; Badalamenti, G.; De Summa, S.; Calabrese, A.; Argentiero, A.; Fucci, L.; Longo, V.; Galetta, D.; Perrotti, P.M.S.; Pinto, R.; Petriella, D.; Danza, K.; Tommasi, S.; Leonetti , F.; Silvestris, N. Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy. Cancers2019, 11, 749.
Brunetti, O.; Badalamenti, G.; De Summa, S.; Calabrese, A.; Argentiero, A.; Fucci, L.; Longo, V.; Galetta, D.; Perrotti, P.M.S.; Pinto, R.; Petriella, D.; Danza, K.; Tommasi, S.; Leonetti , F.; Silvestris, N. Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy. Cancers 2019, 11, 749.
Brunetti, O.; Badalamenti, G.; De Summa, S.; Calabrese, A.; Argentiero, A.; Fucci, L.; Longo, V.; Galetta, D.; Perrotti, P.M.S.; Pinto, R.; Petriella, D.; Danza, K.; Tommasi, S.; Leonetti , F.; Silvestris, N. Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy. Cancers2019, 11, 749.
Brunetti, O.; Badalamenti, G.; De Summa, S.; Calabrese, A.; Argentiero, A.; Fucci, L.; Longo, V.; Galetta, D.; Perrotti, P.M.S.; Pinto, R.; Petriella, D.; Danza, K.; Tommasi, S.; Leonetti , F.; Silvestris, N. Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy. Cancers 2019, 11, 749.
Abstract
Management of multiple primary cancers, a not so infrequent event in oncology practice, is a critical issue due to the lack of literature . In this study, we reported the case of a patient with metachronous double metastatic non small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) who received gefitinib in combination with gemcitabine plus nab-paclitaxel and with mFOLFOX6 in first and second line, respectively. She achieved a progression free survival and an overall survival (OS) of 28 months for NSCLC and PFS-1 and OS of 20 and 13 months, respectively for PDAC. Moreover, the combination of gefitinib and chemotherapies treatments displayed a good safety profile. Given the insignificant frequency of this case, we performed a molecular characterization of both neoplasms with the aim to investigate the existence of particular activated pathways and/or similar immunological mutations. it is interesting to note that two neoplasms shared a commune mutation of B7-H3 gene, with the consecutive impairment of its expressed protein. In both PDAC and NSCLC, the expression of this protein was associated with a worse survival. Since B7-H3 is an anti-apoptotic protein, the reduction of its expression or function should justify a pro-apoptotic activity with a putative justification of the long survival of the patient considered in this report.
Keywords
Pancreatic ductal adenocarcinoma; non small cell lung cancer; double primary cancers; B7-H3; gefitinib; chemotherapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
