Preprint Article Version 1 This version is not peer-reviewed

Wearable Enzymatic Alcohol Biosensor

Version 1 : Received: 4 April 2019 / Approved: 8 April 2019 / Online: 8 April 2019 (15:07:30 CEST)

How to cite: Lansdorp, B.; Ramsay, W.; Hamid, R.; Strenk, E. Wearable Enzymatic Alcohol Biosensor. Preprints 2019, 2019040103 (doi: 10.20944/preprints201904.0103.v1). Lansdorp, B.; Ramsay, W.; Hamid, R.; Strenk, E. Wearable Enzymatic Alcohol Biosensor. Preprints 2019, 2019040103 (doi: 10.20944/preprints201904.0103.v1).

Abstract

Transdermal alcohol biosensors have the ability to detect the alcohol that emanates from the bloodstream and diffuses through the skin. However, they have suffered from long-term fouling of the sensor element and drift in the resulting sensor readings over time. Here, we report a disposable cartridge platform that solves the problem of sensor fouling, and an enzymatic detection pathway that minimizes baseline drift for sensitive detection. Laboratory characterization of the enzymatic alcohol sensor demonstrates a linear sensor range of between 0 and 50 mM. Further, we show continuous transdermal alcohol data recorded with a human subject over 48 hours.

Subject Areas

alcohol; biosensor; cartridge; disposable; transdermal; Alcohol Use Disorder

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