Preprint Article Version 1 This version is not peer-reviewed

MicroRNAs Biomarkers Profiling  in Diagnosis and Therapeutic Management of Hepatitis B Virus Infection

Version 1 : Received: 27 March 2019 / Approved: 28 March 2019 / Online: 28 March 2019 (11:30:39 CET)

How to cite: Niknamian, S. MicroRNAs Biomarkers Profiling  in Diagnosis and Therapeutic Management of Hepatitis B Virus Infection. Preprints 2019, 2019030265 (doi: 10.20944/preprints201903.0265.v1). Niknamian, S. MicroRNAs Biomarkers Profiling  in Diagnosis and Therapeutic Management of Hepatitis B Virus Infection. Preprints 2019, 2019030265 (doi: 10.20944/preprints201903.0265.v1).

Abstract

Introduction: Due to lack of unique method with high accurate and repeatable, assessment and even treatment of  HBV  infection and it,s complications such as cirrhosis and HCC has been with limitations. MicroRNAs (miRNAs) are small 19-24 nucleotide-long molecules with up-regulated and down-regulated Expression.The present research provides a narrative review expression profiling biomarkers miRNAs in diagnosis, treatment and differnciated CHB  from cirrhosis or HCC.Methods: We search database google scholar, pubmed, scopus, SID on English Languish article and also assess  EASL  and  AASLD  (2002-2016).Results: Some of miRNAs are specifically more abundant in specific tissues, such as miR-122 in the liver.    MiRNAs such as miRNA125a, miRNA141, miRNA1, miRNA197, miRNA122 and miRNA372, 373 have a major role in CBH and miRNA29a/b/c, miRNA200, miRNA199, miRNA133a, miRNA214 andmiRNA181b have a major role in fibrosis/cirrhosis. miR-106b and miR-181b, have a significant clinical diagnostic value in liver cirrhosis, especially at its early stages. miR-122, miR-192, miR-92, miR-223, miR-26a, miR-27a and miR-801, has a highly accurate diagnostic power that can differentiate HCC from CHB and cirrhosis and from healthy people as well as.Conclusion: In the future, the miRNAs biomarkers provide researchers with a golden opportunity and can be used as early diagnostic and miRNAs based-therapeutic panels and current knowledge between miRNAs profiling biomarkers and progressive stage of HBV related diseases.  Panels of miRNAs will play a significant role in decision-making about their proper course in both of treatment and diagnosis of diseases such as hepatitis B virus infection.

Subject Areas

Chronic hepatitis B;Epidemiology; Heoatocellular Carcinoma (HCC);cirrhosis; microRNA , HBV, Treatment

Comments (1)

Comment 1
Received: 12 September 2019
Commenter: Patricia lampard
The commenter has declared there is no conflict of interests.
Comment: I was cured of herpes simplex virus 1 & 2 and Hepatitis-b by a great herbal doctor called Robinson Buckler with the use of different combination of Africa herbs. it is still like a dream to me. There is no word suitable enough to qualify your significant in my life dear doctor. You can contact him via [email protected] ( hotmail. ) com, My little way to appreciate you doctor is to advertise your great work and that is what i am doing now ...
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