Preprint Article Version 1 This version is not peer-reviewed

Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine and Oxidative Stress Parameters in Pregnant Women – the Pilot Study

Version 1 : Received: 14 March 2019 / Approved: 15 March 2019 / Online: 15 March 2019 (14:03:35 CET)

How to cite: Argalasova, L.; Zitnanova, I.; Vondrova, D.; Dvorakova, M.; Laubertova, L.; Jurkovicova, J.; Stofko, J.; Weitzman, M.; Simko, M. Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine and Oxidative Stress Parameters in Pregnant Women – the Pilot Study. Preprints 2019, 2019030165 Argalasova, L.; Zitnanova, I.; Vondrova, D.; Dvorakova, M.; Laubertova, L.; Jurkovicova, J.; Stofko, J.; Weitzman, M.; Simko, M. Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine and Oxidative Stress Parameters in Pregnant Women – the Pilot Study. Preprints 2019, 2019030165

Abstract

Abstract: Background: Exposure to ETS (Environmental Tobacco Smoke) is one of the most toxic environmental exposures. Objective: To investigate the impact of ETS on physiological, biochemical, psychological indicators, on the urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. Methods: The exposure to ETS was investigated by a validated questionnaire, urine cotinine and the marker of oxidative damage to lipids - 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric TEAC method. From the sample of pregnant women (n=319, average age 30.84 ± 5.09 years) in 80 the levels of cotinine and oxidative stress markers were analyzed. Results: From our sample, 5 % individuals (7.4 % objectified by cotinine) were current smokers and 25 % reported passive smoking in the household (18.8 % objectified by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS exposed non-smokers. Smokers as well as non-smokers had significantly higher (p<0.05) urine AC than ETS exposed non-smokers. Non-smokers had significantly lower levels of 8-isoprostane than smokers (p<0.01) and ETS-exposed non-smokers (p<0.05). Correlations between urine levels of cotinine and AC were positive in ETS exposed non-smokers. Conclusion: The harmful effect of active and passive smoking on oxidative stress parameters has been indicated.

Subject Areas

Environmental Tobacco Smoke (ETS); pregnant women; questionnaire; urinary cotinine; oxidative stress parameters

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