Preprint Review Version 1 This version is not peer-reviewed

Biogenesis of a Solid Condensate: Amyloid Bodies

Version 1 : Received: 7 March 2019 / Approved: 8 March 2019 / Online: 8 March 2019 (15:12:29 CET)

How to cite: Wang, M.; Lee, S. Biogenesis of a Solid Condensate: Amyloid Bodies. Preprints 2019, 2019030108 (doi: 10.20944/preprints201903.0108.v1). Wang, M.; Lee, S. Biogenesis of a Solid Condensate: Amyloid Bodies. Preprints 2019, 2019030108 (doi: 10.20944/preprints201903.0108.v1).

Abstract

This year marks the 20th anniversary of the discovery that proteins with various cellular functions can be temporarily immobilized in the nucleolus, a process known as nucleolar sequestration. This review reflects on the progress made to understand the physiological roles of nucleolar sequestration and the mechanisms involved in protein immobilization. We discuss how nucleolar sequestration consists of a highly choreographed amyloidogenic liquid-to-solid phase transition that converts the nucleolus into Amyloid bodies (A-bodies). The study of solid condensates A-bodies will offer unique perspectives on cellular assembly of membrane-less compartments and provide alternative insights on pathological amyloidogenesis involved in neurological disorders.

Subject Areas

Nucleolar sequestration, nucleolus, physiological amyloids, ribosomal intergenic spacer, rIGSRNA, liquid-liquid phase separation, liquid-to-solid phase transition, complex coacervation, biomolecular condensates, beta-amyloid, MDM2, VHL, Cdc14, low complexity RNA, acidosis, heat shock

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