Preprint Review Version 1 This version is not peer-reviewed

Systematic Review of Most Common Causes of Acute Pancreatitis

Version 1 : Received: 23 February 2019 / Approved: 25 February 2019 / Online: 25 February 2019 (08:58:59 CET)

How to cite: Carlos, R.; Zilio, M.; Lucas, A.; Fernando, A.; Costas, A. Systematic Review of Most Common Causes of Acute Pancreatitis. Preprints 2019, 2019020220 (doi: 10.20944/preprints201902.0220.v1). Carlos, R.; Zilio, M.; Lucas, A.; Fernando, A.; Costas, A. Systematic Review of Most Common Causes of Acute Pancreatitis. Preprints 2019, 2019020220 (doi: 10.20944/preprints201902.0220.v1).

Abstract

Introduction: Cholelithiasis and consumption of alcohol are the most frequent causes of acute pancreatitis (AP), accounting for about 30 to 40% of the cases, respectively. The frequency of acute biliary pancreatitis is high in a certain population in Brazil. Objective: To estimate the global frequencies of acute biliary pancreatitis (ABP), acute alcoholic pancreatitis (AAP) and the cases considered as acute idiopathic pancreatitis (AIP) in studies published from October 2006 to December 31, 2018. Methods: A systematic review of observational studies was performed from October 2006 to December 31, 2018. A meta-analysis by the random effects model was used to calculate the frequencies of global ABP, AIP and AAP and subgroups. Results: Forty-six studies representing 2,341,007 AP cases were included in 36 countries. The overall estimate for acute biliary pancreatitis (ABP) was 41.6% (95% CI 39.2-44.1), followed by acute alcoholic pancreatitis (AAP) with 20.5% (95% CI) 16.6- 24.6) and acute idiopathic pancreatitis (AIP) in 18.3% (95% CI 15.1-27.7). Conclusion: ABP is the most prevalent etiology of AP, being two times more frequent than second-placed pancreatitis. Latin America has a frequency for ABP much higher than the rest of the world. The importance of the etiologic diagnosis is the treatment of the cause for prevention of recurrence.

Subject Areas

Acute pancreatitis; Etiology; Biliary pancreatitis; Systematic review; Meta-analysis

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.