Preprint Article Version 1 This version is not peer-reviewed

Sustained Release from Injectable Composite Gels Loaded with Silver Nanowires Designed to Combat Bacterial Resistance in Bone Regeneration Applications

Version 1 : Received: 16 February 2019 / Approved: 18 February 2019 / Online: 18 February 2019 (10:38:46 CET)

A peer-reviewed article of this Preprint also exists.

De Mori, A.; Hafidh, M.; Mele, N.; Yusuf, R.; Cerri, G.; Gavini, E.; Tozzi, G.; Barbu, E.; Conconi, M.; Draheim, R.R.; Roldo, M. Sustained Release from Injectable Composite Gels Loaded with Silver Nanowires Designed to Combat Bacterial Resistance in Bone Regeneration Applications. Pharmaceutics 2019, 11, 116. De Mori, A.; Hafidh, M.; Mele, N.; Yusuf, R.; Cerri, G.; Gavini, E.; Tozzi, G.; Barbu, E.; Conconi, M.; Draheim, R.R.; Roldo, M. Sustained Release from Injectable Composite Gels Loaded with Silver Nanowires Designed to Combat Bacterial Resistance in Bone Regeneration Applications. Pharmaceutics 2019, 11, 116.

Journal reference: Pharmaceutics 2019, 11, 116
DOI: 10.3390/pharmaceutics11030116

Abstract

One-dimensional nanostructures such as silver nanowires (AgNWs) have attracted considerable attention owing to their outstanding electrical, thermal and antimicrobial properties; however, their application in the prevention of infections linked to bone tissue regeneration interventions has not yet been explored. Here we report on the development of an innovative scaffold prepared from chitosan, composite hydroxyapatite and AgNWs (CS-HACS-AgNWs) having both bioactive and antibacterial properties. In vitro results highlighted the antibacterial potential of AgNWs against both gram-positive and gram-negative bacteria. The CS-HACS-AgNWs composite scaffold demonstrated suitable Ca/P deposition, improved gel strength, reduced gelation time, and sustained Ag+ release within therapeutic concentrations. Antibacterial studies showed that the composite formulation was capable of inhibiting bacterial growth in suspension and of completely preventing biofilm formation on the scaffold in the presence of resistant strains. The hydrogels were also shown to be biocompatible, allowing cell proliferation. In summary, the developed CS-HACS-AgNWs composite hydrogels demonstrated significant potential as a scaffold material to be employed in bone regenerative medicine, as it presents enhanced mechanical strength combined with the ability to allow calcium salts deposition, while efficiently decreasing the risk of infections. The results presented justify further investigations into potential clinical applications of these materials.

Subject Areas

chitosan hydrogels, silver nanowires, controlled release, antimicrobial activity, bone regeneration

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.