Preprint Concept Paper Version 2 This version is not peer-reviewed

A Tool to Encourage Minimum Reporting GuidelineUptake for Data Analysis in Metabolomics

Version 1 : Received: 22 January 2019 / Approved: 24 January 2019 / Online: 24 January 2019 (08:37:42 CET)
Version 2 : Received: 7 March 2019 / Approved: 8 March 2019 / Online: 8 March 2019 (09:06:02 CET)

A peer-reviewed article of this Preprint also exists.

Considine, E.C.; Salek, R.M. A Tool to Encourage Minimum Reporting Guideline Uptake for Data Analysis in Metabolomics. Metabolites 2019, 9, 43. Considine, E.C.; Salek, R.M. A Tool to Encourage Minimum Reporting Guideline Uptake for Data Analysis in Metabolomics. Metabolites 2019, 9, 43.

Journal reference: Metabolites 2019, 9, 43
DOI: 10.3390/metabo9030043

Abstract

Despite the proposal of minimum reporting guidelines for metabolomics over a decade ago, reporting on the data analysis step in metabolomics studies has been shown to be unclear and incomplete. Major omissions and a lack of logical flow render the data analysis’ sections in metabolomics studies impossible to follow, and therefore replicate or even imitate. Here, we propose possible reasons why the original reporting guidelines have had poor adherence and present an approach to improve their uptake. We present in this paper an R markdown reporting template file that guides the production of text and generates workflow diagrams based on user input. This R Markdown template contains, as an example in this instance, a set of minimum information requirements specifically for the data pre-treatment and data analysis section of biomarker discovery metabolomics studies, (gleaned directly from the original proposed guidelines by Goodacre at al.). These minimum requirements are presented in the format of a questionnaire checklist in an R markdown template file. The R Markdown reporting template proposed here can be presented as a starting point to encourage the data analysis section of a metabolomics manuscript to have a more logical presentation and to contain enough information to be understandable and reusable. The idea is that these guidelines would be open to user feedback, modification and updating by the metabolomics community via GitHub.

Subject Areas

reproducibility; minimum guidelines; reporting; data analysis; reporting

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