Version 1
: Received: 15 January 2019 / Approved: 16 January 2019 / Online: 16 January 2019 (13:14:20 CET)
How to cite:
Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints2019, 2019010168. https://doi.org/10.20944/preprints201901.0168.v1.
Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints 2019, 2019010168. https://doi.org/10.20944/preprints201901.0168.v1.
Cite as:
Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints2019, 2019010168. https://doi.org/10.20944/preprints201901.0168.v1.
Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints 2019, 2019010168. https://doi.org/10.20944/preprints201901.0168.v1.
Abstract
There have been a great number of investigations about the influence of weak magnetic fields on biological systems, such as isolated cells and whole organisms. This is also a subject of considerable medical concern since old epidemiologic observations have indicated a possible tumorigenic effect of these fields. Their mechanism of action, however, is not firmly established. A large number of biological effects of electromagnetic fields have been attributed either to the production of reactive oxygen species (ROS) or to the entrance Ca2+ in the cell. A new biochemical pathway is proposed that covers these two possibilities: the primary effect of the magnetic field would be by the mechanism of radical pairs resulting in the production of ROS; these could activate the ion channels TRPM2 producing cellular inflow of Ca2+, which would induce the calcium dependent effects. Thus, a large number of biological effects observed up to the present could be explained.
Keywords
magnetic field effect; TRPM2; melastatin; calcium channel; reactive oxygen species; radical pairs
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
