Preprint Article Version 1 This version is not peer-reviewed

Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2

Version 1 : Received: 15 January 2019 / Approved: 16 January 2019 / Online: 16 January 2019 (13:14:20 CET)

How to cite: Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints 2019, 2019010168 (doi: 10.20944/preprints201901.0168.v1). Mantovani, B. Mechanism of Action of Extremely Low Frequency or Static Magnetic Fields on Cells: Role of Oxidative Activation of TRPM2. Preprints 2019, 2019010168 (doi: 10.20944/preprints201901.0168.v1).

Abstract

There have been a great number of investigations about the influence of weak magnetic fields on biological systems, such as isolated cells and whole organisms. This is also a subject of considerable medical concern since old epidemiologic observations have indicated a possible tumorigenic effect of these fields. Their mechanism of action, however, is not firmly established. A large number of biological effects of electromagnetic fields have been attributed either to the production of reactive oxygen species (ROS) or to the entrance Ca2+ in the cell. A new biochemical pathway is proposed that covers these two possibilities: the primary effect of the magnetic field would be by the mechanism of radical pairs resulting in the production of ROS; these could activate the ion channels TRPM2 producing cellular inflow of Ca2+, which would induce the calcium dependent effects. Thus, a large number of biological effects observed up to the present could be explained.

Subject Areas

magnetic field effect; TRPM2; melastatin; calcium channel; reactive oxygen species; radical pairs

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.