Preprint Review Version 1 This version is not peer-reviewed

Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature

Version 1 : Received: 10 December 2018 / Approved: 12 December 2018 / Online: 12 December 2018 (05:22:13 CET)

A peer-reviewed article of this Preprint also exists.

Badat, N.; Abdulhussein, D.; Oligbu, P.; Ojubolamo, O.; Oligbu, G. Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature. Pharmacy 2019, 7, 3. Badat, N.; Abdulhussein, D.; Oligbu, P.; Ojubolamo, O.; Oligbu, G. Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature. Pharmacy 2019, 7, 3.

Journal reference: Pharmacy 2018, 7, 3
DOI: 10.3390/pharmacy7010003

Abstract

Dengue virus (DENV) is the most common arbovirus disease, with wide spectrum of presentation. Spinal cord involvement in dengue infection (DF) is rare. However, the risk of transverse myelitis (TM) following Dengue has not been systematically assessed. Methods: We undertook a systematic review of the English literature published from January 1974 to December 2017 to assess risk of TM and outcomes following DF. Data sources included MEDLINE, EMBASE Cochrane library, and references within identified articles. Results: We identified 242 potential studies, 62 were duplicates. A further 136 were excluded on the basis of title and abstract and 19 studies did not meet the eligibility criteria on full text screening. We included 25 publications involving 2672 cases of DF. 10.8% (289/2672) had neurological complications, of which 2.3% (61/2672) was TM. For articles reporting epidemiological data, the neurological complication was twice in males compared to female 67.7% (130/192) vs 32.7% (62/192) and 1.5 fold increase TM for males 59.3% (32/54) vs 40.7% (22/54). The mean age at presentation was 33.1years (Range 0.75 – 61), with onset at 11.7days. The method of diagnosing TM due to DF was mainly IgM seropositivity 92% (n=23/25) and the commonest treatment modality was steroid 78.3% (n=18/23). Only half had full recovery 50.8% (n=31/61). There was no mortality following dengue, however, the crude case fatality rate following TM was 3.3% (n=2/61). Conclusion:  This review highlights the risk of TM following dengue. Although neurological complications are rare, especially TM, once set in, it is associated with a significant morbidity.

Subject Areas

dengue fever; transverse myelitis; risk; systematic review

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