Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Expression of the Components of the Renin-Angiotensin System in Oncological Diseases

Version 1 : Received: 30 November 2018 / Approved: 3 December 2018 / Online: 3 December 2018 (04:27:03 CET)

A peer-reviewed article of this Preprint also exists.

Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21. Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21.

Journal reference: Acta clinica Croatica 2019, 58, 354-363
DOI: 10.20471/acc.2019.58.02.21

Abstract

Analyzed the literature devoted to the changes in the expression of the RAS proteins of cancer cells. A brief review of protein expression dynamics PAC in malignant tumors and the possible role of epigenetic mechanisms in these processes. Through research epigenetic mechanisms state for cancer have been developed principally new techniques for their correction, based on the use of selective regulators systems covalent modification-histone proteins (for example, deacetylase inhibitor) and microRNA synthesis technologies. Literature data show promising pharmacological correction epigenetic modification of chromatin in the treatment of cancer.

Subject Areas

oncology; ectopic RAS cancer cells; epigenetic stimulation PAC in oncology

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