Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21.
Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21.
Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21.
Dolomatov, Sergey; Zukow, Walery; Novikov, Nikolay; Markaryan, Alexandra; Eremeeva, Elena. Expression of the components of the renin-angiotensin system in oncological diseases = Izraženost sastavnica sustava renin-angiotenzin kod onkoloških bolesti. Acta Clinica Croatica. 2019; 58(2): 354-364. https://doi.org/10.20471/acc.2019.58.02.21.
Abstract
Analyzed the literature devoted to the changes in the expression of the RAS proteins of cancer cells. A brief review of protein expression dynamics PAC in malignant tumors and the possible role of epigenetic mechanisms in these processes. Through research epigenetic mechanisms state for cancer have been developed principally new techniques for their correction, based on the use of selective regulators systems covalent modification-histone proteins (for example, deacetylase inhibitor) and microRNA synthesis technologies. Literature data show promising pharmacological correction epigenetic modification of chromatin in the treatment of cancer.
Keywords
oncology; ectopic RAS cancer cells; epigenetic stimulation PAC in oncology
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
