Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture
Version 2 : Received: 24 January 2019 / Approved: 25 January 2019 / Online: 25 January 2019 (11:36:58 CET)
How to cite: Rubio, N.; Datar, I.; Stachura, D.; Krueger, K. Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture. Preprints 2018, 2018110326 (doi: 10.20944/preprints201811.0326.v2). Rubio, N.; Datar, I.; Stachura, D.; Krueger, K. Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture. Preprints 2018, 2018110326 (doi: 10.20944/preprints201811.0326.v2).
Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production.
Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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