Preprint Article Version 1 This version is not peer-reviewed

Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction

Version 1 : Received: 12 November 2018 / Approved: 13 November 2018 / Online: 13 November 2018 (10:56:25 CET)

A peer-reviewed article of this Preprint also exists.

Komici, K.; Vitale, D.F.; Mancini, A.; Bencivenga, L.; Conte, M.; Provenzano, S.; Grieco, F.V.; Visaggi, L.; Ronga, I.; Cittadini, A.; Corbi, G.; Trimarco, B.; Morisco, C.; Leosco, D.; Ferrara, N.; Rengo, G. Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction. Nutrients 2019, 11, 224. Komici, K.; Vitale, D.F.; Mancini, A.; Bencivenga, L.; Conte, M.; Provenzano, S.; Grieco, F.V.; Visaggi, L.; Ronga, I.; Cittadini, A.; Corbi, G.; Trimarco, B.; Morisco, C.; Leosco, D.; Ferrara, N.; Rengo, G. Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction. Nutrients 2019, 11, 224.

Journal reference: Nutrients 2019, 11, 224
DOI: 10.3390/nu11020224

Abstract

Background: Malnutrition is a frequent condition in the elderly and is associated with prolonged hospitalization and increased mortality. However, the impact of malnutrition among elderly patients with acute myocardial infarction has not been clarified yet. Methods and Results: We have enrolled 174 patients aged 65 years and over, admitted with the diagnosis of acute myocardial infarction (AMI) who underwent to the evaluation of nutritional status by Mini Nutritional Assessment (MNA) and of mortality risk by Grace score 2.0. All-cause mortality was the outcome considered for this study. Over a mean follow-up of 24.5 ± 18.2 months, 43 deaths have been registered (24.3%). Non-survivors were more likely to be older, with worse GFR, lower SBP, lower albumin and MNA score, higher prevalence of Killip classification III-IV grade, and higher Troponin I levels. Multivariate Cox proportional analysis revealed that Grace score and MNA showed a significant and independent impact on mortality, (HR = 1.76, 95% CI = 1.34–2.32 and HR = 0.56, 95% CI = 0.42–0.73, respectively). Moreover, the clinical decision curve revealed a higher clinical net benefit when the MNA was included compared to the partial models without MNA. Conclusions: Nutritional status is an independent predictor of long-term mortality among elderly patients with AMI. MNA score in elderly patients with AMI may help prognostic stratification and identification of patients with/at risk of malnutrition in order to apply interventions to improve nutritional status and maybe survival in this population.

Subject Areas

mini nutritional assessment; acute myocardial infarction; mortality; elderly

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