Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Two-Year Data Comparison of Ab Interno Trabeculectomy and Trabecular Bypass Stenting Using Exact Matching

Version 1 : Received: 2 November 2018 / Approved: 5 November 2018 / Online: 5 November 2018 (15:29:14 CET)
Version 2 : Received: 30 November 2018 / Approved: 3 December 2018 / Online: 3 December 2018 (08:46:35 CET)

How to cite: Esfandiari, H.; Taubenslag, K.; Shah, P.; Goyal, S.; Weiner, A.J.; Severson, M.L.; Weiner, A.; Grove, D.S.; Bussel, I.I.; Loewen, N.A. Two-Year Data Comparison of Ab Interno Trabeculectomy and Trabecular Bypass Stenting Using Exact Matching. Preprints 2018, 2018110109. https://doi.org/10.20944/preprints201811.0109.v2 Esfandiari, H.; Taubenslag, K.; Shah, P.; Goyal, S.; Weiner, A.J.; Severson, M.L.; Weiner, A.; Grove, D.S.; Bussel, I.I.; Loewen, N.A. Two-Year Data Comparison of Ab Interno Trabeculectomy and Trabecular Bypass Stenting Using Exact Matching. Preprints 2018, 2018110109. https://doi.org/10.20944/preprints201811.0109.v2

Abstract

Purpose: To create a highly balanced comparison of ab interno trabeculectomy (Trabectome, AIT) and trabecular bypass stenting (iStent, TBS).Setting: Eye and Ear Institute, Pittsburgh, Ross Eye Institute, Buffalo, and Glaucoma Associates of Texas, Dallas, USA.Design: Retrospective Exact Matching analysis.Methods: AIT and TBS patients were included from three large glaucoma practices. The primary outcome measure was the unmedicated IOP ≤ 21 mmHg at 2-year follow-up visit. A secondary measure was unmedicated IOP reduction ≥ 20% at 2 years. Patients were matched by baseline IOP, the number of glaucoma medications and glaucoma type using Exact Matching and by age using Nearest Neighbor matching. Patients without a close match were excluded. All surgeries were combined with phacoemulsification. Results: 154 AIT and 110 TBS eyes were analyzed. 48 AIT patients were exactly matched to 48 TBS patients. Both groups had a baseline IOP of 15.3±3.1 mmHg. At 24 months, the mean IOP was 13.9±3.3 for AIT versus 16.8±2.8 mmHg for TBS (p=0.04), while the number of medications was 0.7±1.0 for AIT versus 1.7±1.2 for TBS (p=0.04). The proportion of subjects achieving IOP ≤ 21 mmHg without medications at 24 months was 53% in AIT versus 16.6% in TBS (P < 0.05). At 24-month follow up 17.6% of patients in AIT had ≥ 20% IOP reduction without medication versus no patient in TBS. Conclusions: An Exact Matching comparison of AIT and TBS demonstrated greater IOP reduction with fewer medications in AIT.

Keywords

ab interno trabeculectomy, trabectome surgery, iStent, phacoemulsification, glaucoma surgery

Subject

Medicine and Pharmacology, Ophthalmology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.